精子 DNA 碎片化：对生殖的影响。
Sperm DNA Fragmentation: Consequences for Reproduction.
机构信息
Department of Surgery (Urology), University of Utah School of Medicine, Salt Lake City, UT, USA.
Andrology and IVF Laboratories, Department of Surgery, and Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
Adv Exp Med Biol. 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6.
DNA fragmentation, or the accumulation of single- and double-strand DNA breaks, is a common property of sperm, and an increase in the level of sperm DNA fragmentation is known to influence natural reproduction. The effect of sperm DNA fragmentation on male infertility and assisted reproductive treatment (ART) outcomes remains controversial and is one of the most frequently debated topics of reproductive medicine. For the past 30 years, a number of assays have been developed to quantify the level of sperm DNA fragmentation. In this chapter, we review the causes of sperm DNA fragmentation, describe the commonly used tests to evaluate these abnormalities, and perform a systematic review of existing studies to determine the impact of sperm DNA fragmentation on male fertility and ART outcomes.
DNA 碎片化，或单链和双链 DNA 断裂的积累，是精子的一个常见特性，已知精子 DNA 碎片化程度的增加会影响自然生殖。精子 DNA 碎片化对男性不育和辅助生殖治疗 (ART) 结局的影响仍然存在争议，是生殖医学中最常被讨论的话题之一。在过去的 30 年中，已经开发出许多检测方法来量化精子 DNA 碎片化的水平。在本章中，我们回顾了精子 DNA 碎片化的原因，描述了常用于评估这些异常的检测方法，并对现有研究进行了系统回顾，以确定精子 DNA 碎片化对男性生育力和 ART 结局的影响。
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