GReD Laboratory, CNRS UMR6293 - INSERM U1103 - Université Clermont Auvergne, Faculté de Médecine, Clermont-Ferrand, France.
Priority Research Centre for Reproductive Science, Faculty of Science, University of Newcastle, Callaghan, NSW, Australia.
Adv Exp Med Biol. 2019;1166:107-117. doi: 10.1007/978-3-030-21664-1_7.
Due to its particular "silent" metabolic state, without transcription or translation, and a low level of cytosolic protective activities, mature sperm is a cellular type of aerobic organisms particularly at risk of oxidative damage. Despite the efforts of the male genital tract to treat this problem, a subcellular compartment of the sperm, the nucleus, and consequently, the paternal DNA cannot be effectively protected. There is an accumulation of evidence that oxidative damage to sperm DNA is quite common in male infertilities/subfertilities with potential harmful impacts on reproductive success, including the transgenerational inheritance of a paternal chromosomal lot carrying mutations.
由于其特殊的“静默”代谢状态，没有转录或翻译，以及细胞质保护活性水平低，成熟精子是有氧生物的一种细胞类型，特别容易受到氧化损伤。尽管男性生殖道努力解决这个问题，但精子的一个亚细胞区室，即细胞核，以及随之而来的父系 DNA 不能得到有效保护。有越来越多的证据表明，精子 DNA 的氧化损伤在男性不育/低育症中很常见，这可能对生殖成功产生潜在的有害影响，包括携带突变的父系染色体的跨代遗传。
