III 型分泌系统的针、尖端和转位器。
The type III secretion system needle, tip, and translocon.
机构信息
Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas.
出版信息
Protein Sci. 2019 Sep;28(9):1582-1593. doi: 10.1002/pro.3682. Epub 2019 Aug 2.
Abstract
Many Gram-negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic resistance. The T3SS is an attractive target for developing new antibiotics because it is essential in virulence, and part of its structural component is exposed on the bacterial surface. The structural component of the T3SS is the needle apparatus, which is assembled from over 20 different proteins and consists of a base, an extracellular needle, a tip, and a translocon. This review summarizes the current knowledge on the structure and assembly of the needle, tip, and translocon.
摘要
许多对动植物具有致病性的革兰氏阴性菌利用 III 型分泌系统（T3SS）将毒力因子注入宿主细胞。所有依赖 T3SS 在人类中引起传染病的细菌都产生了抗生素耐药性。T3SS 是开发新型抗生素的有吸引力的靶标，因为它是毒力所必需的，并且其结构组件的一部分暴露在细菌表面。T3SS 的结构组件是针状装置，它由超过 20 种不同的蛋白质组装而成，包括基部、细胞外针、尖端和转位器。本文综述了目前关于针、尖端和转位器的结构和组装的知识。
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