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Visualization of the type III secretion mediated -host cell interface using cryo-electron tomography.利用冷冻电镜断层扫描技术可视化 III 型分泌系统介导的 -宿主细胞界面。
Elife. 2018 Oct 3;7:e39514. doi: 10.7554/eLife.39514.
2
Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin.冷冻电镜分析 T3S 注射器揭示了针和开放分泌孔的结构。
Nat Commun. 2018 Sep 21;9(1):3840. doi: 10.1038/s41467-018-06298-8.
3
The type III secretion translocator PopB assists the insertion of the PopD translocator into host cell membranes.III 型分泌系统转运器 PopB 协助 PopD 转运器插入宿主细胞膜。
J Biol Chem. 2018 Jun 8;293(23):8982-8993. doi: 10.1074/jbc.RA118.002766. Epub 2018 Apr 23.
4
Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome.铜绿假单胞菌 III 型分泌系统通道的孔形成活性改变宿主的表观基因组。
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5
Characterization of Small-Molecule Scaffolds That Bind to the Shigella Type III Secretion System Protein IpaD.与志贺氏菌Ⅲ型分泌系统蛋白IpaD结合的小分子支架的表征
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6
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Nat Rev Microbiol. 2017 Jun;15(6):323-337. doi: 10.1038/nrmicro.2017.20. Epub 2017 Apr 10.
7
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8
NMR identification of the binding surfaces involved in the Salmonella and Shigella Type III secretion tip-translocon protein-protein interactions.核磁共振鉴定沙门氏菌和志贺氏菌III型分泌尖端转运蛋白-蛋白相互作用中涉及的结合表面。
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9
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10
Bacterial Secretion Systems: An Overview.细菌分泌系统：概述。
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III 型分泌系统的针、尖端和转位器。

The type III secretion system needle, tip, and translocon.

机构信息

Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas.

出版信息

Protein Sci. 2019 Sep;28(9):1582-1593. doi: 10.1002/pro.3682. Epub 2019 Aug 2.

DOI:10.1002/pro.3682
PMID:31301256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6699086/
Abstract

Many Gram-negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic resistance. The T3SS is an attractive target for developing new antibiotics because it is essential in virulence, and part of its structural component is exposed on the bacterial surface. The structural component of the T3SS is the needle apparatus, which is assembled from over 20 different proteins and consists of a base, an extracellular needle, a tip, and a translocon. This review summarizes the current knowledge on the structure and assembly of the needle, tip, and translocon.

摘要

许多对动植物具有致病性的革兰氏阴性菌利用 III 型分泌系统（T3SS）将毒力因子注入宿主细胞。所有依赖 T3SS 在人类中引起传染病的细菌都产生了抗生素耐药性。T3SS 是开发新型抗生素的有吸引力的靶标，因为它是毒力所必需的，并且其结构组件的一部分暴露在细菌表面。T3SS 的结构组件是针状装置，它由超过 20 种不同的蛋白质组装而成，包括基部、细胞外针、尖端和转位器。本文综述了目前关于针、尖端和转位器的结构和组装的知识。