Carvalho Wágner do Nascimento, Gonçalves Karla Cordeiro, Miranda Anna Letícia, Maria Gustavo Dos Santos Alves, de Fátima Silqueira Salete Maria, Moreira Maria da Consolação Vieira
Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Transplant Proc. 2019 Jul-Aug;51(6):1684-1688. doi: 10.1016/j.transproceed.2019.05.011. Epub 2019 Jul 10.
Brazil's transplant network is a consolidated, worldwide-recognized program, with about 96% of heart transplantations (HTs) financed by its Unified Health System. It is known that the number of HTs has risen in the past few years, but it still does not meet the demand. This study aims to characterize the profile of the heart donors of a Brazilian center and ascertain the factors contributing to the increase in number of HTs.
This is a cross-sectional and analytical study, developed between 2012 and 2018 at a Brazilian transplant center.
There were 210 donations for HT in this period. The median age of donors in years (range) was 33 (24-40), and the donors were 15.5 years younger than the recipients (P value < .001). One hundred forty-two donors (67.6%) were male, 98 (46.7%) were mullato, and 115 (54.8%) had cranioencephalic trauma as the cause of brain death. The distance from the transplant center to the organ procurement area was short in 183 (87.1%) cases, enabling a allograft ischemic time with a median of 125 minutes. There was a relevant association between donor age and cause of brain death (P < .001), sex and cause of brain death (P < .001), and organ procurement area and allograft ischemic time (P < .001). Hospitals that provide urgent and emergency care served as sources for a larger number of organ donations.
This study concluded that the profile of most donors for HT include young adult mullato men who were victims of cranioencephalic trauma. In addition, these donors had few comorbidities and a median age of 33 years.
巴西的移植网络是一个成熟的、全球认可的项目，约96%的心脏移植（HT）由其统一卫生系统提供资金。众所周知，过去几年HT的数量有所增加，但仍未满足需求。本研究旨在描述巴西一个中心心脏供体的特征，并确定导致HT数量增加的因素。
这是一项横断面分析研究，于2012年至2018年在巴西一个移植中心开展。
在此期间有210例用于HT的捐赠。供体的年龄中位数（范围）为33岁（24 - 40岁），供体比受体年轻15.5岁（P值 <.001）。142名供体（67.6%）为男性，98名（46.7%）为混血儿，115名（54.8%）因颅脑创伤导致脑死亡。在183例（87.1%）病例中，移植中心到器官获取区域的距离较短，使得同种异体移植物缺血时间中位数为125分钟。供体年龄与脑死亡原因（P <.001）、性别与脑死亡原因（P <.001）以及器官获取区域与同种异体移植物缺血时间（P <.001）之间存在显著关联。提供紧急和急诊护理的医院是更多器官捐赠的来源。
本研究得出结论，大多数HT供体的特征包括年轻的成年混血男性，他们是颅脑创伤的受害者。此外，这些供体合并症较少，年龄中位数为33岁。
