双胞胎研究表明脑脊液中单核细胞趋化蛋白-1与犬尿氨酸之间存在关联。

Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.

作者信息

Johansson Viktoria, Erhardt Sophie, Engberg Göran, Kegel Magdalena, Bhat Maria, Schwieler Lilly, Blennow Kaj, Zetterberg Henrik, Cannon Tyrone D, Wetterberg Lennart, Hultman Christina M, Landén Mikael

机构信息

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, 171 77, Stockholm, Sweden.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, 11364, Stockholm, Sweden.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2020 Oct;270(7):933-938. doi: 10.1007/s00406-019-01042-9. Epub 2019 Jul 13.

DOI:10.1007/s00406-019-01042-9

PMID:31302732

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7474706/

Abstract

Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed.

摘要

临床前研究表明犬尿氨酸途径与单核细胞趋化蛋白-1（MCP-1）之间存在联系，但缺乏进一步研究此联系的临床研究。我们在此对23对患精神分裂症、双相情感障碍或未患病的双胞胎的脑脊液中的犬尿氨酸代谢物和MCP-1进行了二次分析。我们发现，受独特环境影响，MCP-1与犬尿喹啉酸（KYNA）之间存在关联，而MCP-1与色氨酸之间的关联则不太明显。未检测到MCP-1与喹啉酸之间存在关联。需要进一步研究KYNA与MCP-1之间假定关系背后的机制。