细针穿刺活检诊断菊池病。

Diagnosing Kikuchi's disease on fine needle aspiration biopsy.

机构信息

Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

出版信息

Cytopathology. 2020 Jan;31(1):22-25. doi: 10.1111/cyt.12754. Epub 2019 Sep 1.

DOI:10.1111/cyt.12754

PMID:31302946

Abstract

OBJECTIVE

To investigate the diagnostic utility of fine needle aspiration (FNA) smear, cell block (CB), flow cytometry (FC) and tuberculosis polymerase chain reaction (Tb-PCR) analysis for Kikuchi's disease (KD).

METHODS

A total of 173 FNA biopsy samples were collected using a Youyi aspirator. KD was diagnosed by FNA smear, with or without, CB, FC and Tb-PCR.

RESULTS

Out of 173 patients, 131 (75.7%) were female and 126 (72.8%) aged 21-40 years. Of these, 171 patients (98.8%) presented with painful enlarged cervical lymph nodes. All cytological samples identified intracellular apoptotic debris embedded in the cytoplasm of crescentic and phagocytic macrophages. In 24 cell-blocks (CBs), clusters of CD123 positive plasmacytoid monocytes were observed in KD. FC and CBs showed non-specific lymphoid hyperplasia in nine cases with suspicious lymphoma. Tb-PCR was negative in five cases with suspicion of tuberculosis.

CONCLUSIONS

In summary, FNA biopsy is a fast, reliable, and relatively inexpensive diagnosis tool for KD. CB preparation is an important adjunct method for the diagnosis of KD.

摘要

目的

探讨细针抽吸（FNA）涂片、细胞块（CB）、流式细胞术（FC）和结核分枝杆菌聚合酶链反应（Tb-PCR）分析在诊断组织细胞坏死性淋巴结炎（KD）中的诊断价值。

方法

使用游艺 18G 型一次性自动活检枪收集了 173 例 FNA 活检样本。通过 FNA 涂片、FNA 涂片联合 CB、FC 和 Tb-PCR 联合检测对 KD 进行诊断。

结果

在 173 例患者中，131 例（75.7%）为女性，126 例（72.8%）年龄在 21-40 岁。其中，171 例（98.8%）患者表现为疼痛性、肿大的颈淋巴结。所有细胞学标本均识别出细胞内凋亡碎片，嵌入新月形和吞噬性巨噬细胞的细胞质中。在 24 例 CB 中，KD 中观察到 CD123 阳性浆细胞的簇状。FC 和 CB 在 9 例疑似淋巴瘤的病例中显示非特异性淋巴组织增生。5 例疑似结核的病例 Tb-PCR 为阴性。