Erasmus MC, University Medical Centre Rotterdam, Department of Surgery, Division of HPB & Transplant Surgery, Dr. Molewaterplein 40, 3015, GD, Rotterdam, the Netherlands; The Medical University of Warsaw, Department of General and Transplantation Surgery, Nowogrodzka 59 St, 02-006 Warsaw, Poland.
Erasmus MC, University Medical Centre Rotterdam, Department of Surgery, Division of HPB & Transplant Surgery, Dr. Molewaterplein 40, 3015, GD, Rotterdam, the Netherlands; Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Gastroenterological Surgery, 2-5-1 Shikatacho, Kita-ku, Okayama-shi, Okayama, Japan.
Transplant Rev (Orlando). 2019 Oct;33(4):209-218. doi: 10.1016/j.trre.2019.06.004. Epub 2019 Jul 2.
The aim of this systematic review and meta-analysis was to present the outcome of deceased adult liver transplantation from octogenarian (≥80 years old) donors compared to younger grafts.
A systematic search was performed on six databases to identify all available original papers that report the outcome of adult recipients who underwent liver transplantation from a deceased octogenarian donor.
Overall, 39,034 liver transplantations from 12 studies were reported with 789 (2.02%) cases receiving grafts from octogenarian donors. Eight studies were included in the meta-analysis. There was no difference regarding the one, three, and five-year graft and patient survival between the recipients of livers <80 years old and octogenarian grafts. There were significantly more episodes of biliary complications in the recipients of octogenarian grafts (34/459; 7.4%) in comparison to the recipients of livers <80 years old (372/37074; 1.0%) (OR 0.53; 95% CI = 0.35-0.81; P 0.004; I = 0%). The incidence of primary non-function, vascular complications and re-transplantation did not differ between groups.
The short- and medium-term graft and patient survival of octogenarian liver transplantation is not inferior compared to the liver transplantation with younger grafts, however with a higher rate of biliary complications.
本系统评价和荟萃分析的目的是展示与年轻供体相比，从 80 岁以上（≥80 岁）老年人供体中获取的成人肝移植的结果。
在六个数据库中进行了系统搜索，以确定所有报告接受 80 岁以上老年人供体肝移植的成人受者结果的可用原始论文。
共有来自 12 项研究的 39034 例肝移植报告，其中 789 例（2.02%）接受 80 岁以上老年人供体的移植物。有 8 项研究纳入荟萃分析。在接受<80 岁供体肝和 80 岁以上供体肝的受者中，1 年、3 年和 5 年移植物和患者存活率没有差异。接受 80 岁以上供体肝的受者（34/459；7.4%）与接受<80 岁供体肝的受者（372/37074；1.0%）相比，胆道并发症的发生率明显更高（OR 0.53；95%CI=0.35-0.81；P<0.004；I=0%）。原发性无功能、血管并发症和再次移植的发生率在两组之间没有差异。
与年轻供体的肝移植相比，80 岁以上老年人肝移植的短期和中期移植物和患者存活率并不差，但胆道并发症的发生率更高。
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