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对于超过三分之二的 Garden I 型髋部骨折患者,非手术治疗是一种可靠的选择。298 例患者的失败率和危险因素。

Non-operative treatment is a reliable option in over two thirds of patients with Garden I hip fractures. Rates and risk factors for failure in 298 patients.

机构信息

CNRS, ISM UMR 7287, Aix-Marseille université, 13288 Marseille cedex 09, France; Department of orthopaedics and traumatology, institute of movement and locomotion, St. Marguerite hospital, 13009 Marseille, France.

CNRS, ISM UMR 7287, Aix-Marseille université, 13288 Marseille cedex 09, France; Department of orthopaedics and traumatology, institute of movement and locomotion, St. Marguerite hospital, 13009 Marseille, France.

出版信息

Orthop Traumatol Surg Res. 2019 Sep;105(5):985-990. doi: 10.1016/j.otsr.2019.04.021. Epub 2019 Jul 11.

Abstract

BACKGROUND

Non-operative treatment for impacted femoral neck fractures is a now rarely used strategy whose indications are controversial. No outcome predictors have been convincingly identified, in part due to the small sizes of available studies. We conducted a large retrospective study with the following objectives: (1) to evaluate the percentage of patients older than 65 years of age with non-operatively treated Garden I femoral neck fractures who experience secondary displacement, (2) to identify predictors of secondary displacement, and (3) to determine the frequency of non-operative treatment failure due to any cause and requiring joint replacement surgery.

HYPOTHESIS

Non-operative treatment is reliable in patients older than 65 years of age with Garden I femoral neck fractures.

MATERIAL AND METHODS

Approval was obtained from the French data protection authority to conduct a retrospective observational study of information in the Marseille university hospitals database. Consecutive patients who were older than 65 years of age at traumatology department admission for Garden I femoral neck fractures managed non-operatively between January 2007 and December 2017 were included. Non-operative treatment consisted in a walking test on day 1 followed by radiographs on days 2, 7, 14, 21, and 45 and after 3 and 12 months. Patients with secondary displacement underwent hip arthroplasty. Demographic data, cognitive performance, and radiological parameters were collected for each patient. We evaluated the rates of secondary displacement avascular necrosis, and non-union.

RESULTS

We included 298 patients with a mean age of 82 years (range, 65-101). Mean follow-up was 5±3 years. Secondary displacement occurred in 91 (30%) patients, at a mean of 16 days (range 2-45 days) after the fracture. Avascular necrosis of the femoral head developed in 13 (4.3%) patients and non-union in 11 (3.7%) patients. Secondary displacement was significantly associated with hypnotic treatment (OR, 4.1; 95%CI, 2.2-7.5; p=0.039), institutionalisation (OR, 6.7; 95%CI, 3.1-14.8; p=0.028), a history of repeated falls (OR, 13.5; 95%CI, 6.3-8.4; p<0.0001), having three or more comorbidities (OR, 3.2; 95%CI, 1.7-5.8; p=0.046), and having dementia (OR, 3.5; 95%CI, 1.7-6.9; p=0.0003). Secondary displacement occurred in 18 (12%) of the 151 community-dwelling patients with normal cognition and no history of repeated falls compared to 37 (75%) of the 50 institutionalised patients with dementia.

DISCUSSION

Non-operative treatment was effective in 196 (66%) of 298 patients with Garden I femoral neck fractures. Significant risk factors for secondary displacement were dementia, institutionalisation, hypnotic treatment, multiple comorbidities, and a history of repeated falls. Of 151 community-dwelling patients with normal cognition and no repeated falls, 133 (88%) achieved a full recovery with non-operative treatment alone.

LEVEL OF EVIDENCE

IV, retrospective cohort study.

摘要

背景

非手术治疗股骨颈骨折已很少使用,其适应证存在争议。由于现有研究的样本量较小,因此尚未明确可靠的预后预测指标。我们进行了一项大型回顾性研究,旨在:(1)评估Garden I 型股骨颈骨折非手术治疗的 65 岁以上患者中发生继发性移位的比例;(2)确定继发性移位的预测因素;(3)确定因任何原因导致非手术治疗失败并需要关节置换手术的频率。

假设

对于 65 岁以上的 Garden I 型股骨颈骨折患者,非手术治疗是可靠的。

材料和方法

获得法国数据保护局的批准,对马赛大学附属医院数据库中的信息进行回顾性观察性研究。纳入 2007 年 1 月至 2017 年 12 月期间因股骨颈骨折(Garden I 型)接受非手术治疗的 65 岁以上创伤科住院患者。非手术治疗包括第 1 天行走试验,随后在第 2、7、14、21 和 45 天以及 3 个月和 12 个月时进行 X 线检查。发生继发性移位的患者行髋关节置换术。收集每位患者的人口统计学数据、认知表现和影像学参数。我们评估了继发性移位、股骨头缺血性坏死和骨不连的发生率。

结果

我们纳入了 298 名平均年龄为 82 岁(范围 65-101 岁)的患者。平均随访时间为 5±3 年。91 名(30%)患者发生继发性移位,平均发生于骨折后 16 天(范围 2-45 天)。13 名(4.3%)患者发生股骨头缺血性坏死,11 名(3.7%)患者发生骨不连。继发性移位与催眠治疗(OR,4.1;95%CI,2.2-7.5;p=0.039)、住院治疗(OR,6.7;95%CI,3.1-14.8;p=0.028)、反复跌倒史(OR,13.5;95%CI,6.3-8.4;p<0.0001)、存在三种或三种以上合并症(OR,3.2;95%CI,1.7-5.8;p=0.046)和痴呆(OR,3.5;95%CI,1.7-6.9;p=0.0003)显著相关。在认知正常且无反复跌倒史的 151 名社区居住患者中,18 名(12%)发生继发性移位,而在有痴呆且住院治疗的 50 名患者中,37 名(75%)发生继发性移位。

讨论

298 名股骨颈骨折患者中,196 名(66%)接受非手术治疗有效。继发性移位的显著危险因素包括痴呆、住院治疗、催眠治疗、多种合并症和反复跌倒史。在认知正常且无反复跌倒史的 151 名社区居住患者中,133 名(88%)仅接受非手术治疗即可完全康复。

证据水平

IV,回顾性队列研究。

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