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酷似Hallopeau连续性肢端皮炎的结痂性疥疮

Crusted scabies mimicking an acrodermatitis continua of Hallopeau.

作者信息

Roldán-Franco María S, de Nitsch Myriam J Yat-Juárez, Sarti Helga M

机构信息

Instituto de Dermatologíaa y Cirugía de Piel. Ciudad de Guatemala, Guatemala.

Piel Saludable. Ciudad de Guatemala, Guatemala.

出版信息

Bol Med Hosp Infant Mex. 2019;76(4):198-202. doi: 10.24875/BMHIM.19000012.

Abstract

BACKGROUND

Crusted scabies (CS) is an uncommon, highly contagious, variant of classic scabies. Elevated concentrations of the mite Sarcoptes scabiei var. hominis are found in the skin lesions, which lead to a more exaggerated clinical picture than in classic scabies. This disease is mainly observed in patients with any kind of immunosuppression and relates to Down syndrome.

CASE REPORT

A pediatric female patient with Down syndrome, who presented a crusty white plaque associated with nail dystrophy and subungual hyperkeratosis affecting the distal portion of the fingers is described. Because of these findings, the diagnosis of acrodermatitis continua of Hallopeau was considered. A punch biopsy was performed, attaining the diagnosis of CS. She received systemic treatment with oral ivermectin, topical treatment with emollient cream and desonide 0.1%. Notorious clinical improvement was observed two weeks after finalizing treatment.

CONCLUSIONS

CS is variant of scabies prevalent in immunocompromised patients and Down syndrome that can be easily confused with inflammatory pathologies with abnormal epidermal keratinization. This case is considered as an atypical presentation of the disease because of local affection of the fingers and nail dystrophy. The histopathological study was necessary to obtain the diagnosis and rule out differential diagnosis.

摘要

背景

结痂性疥疮(CS)是一种罕见的、高度传染性的经典疥疮变种。在皮肤病变中发现人疥螨浓度升高,这导致其临床表现比经典疥疮更为严重。这种疾病主要见于任何类型免疫抑制的患者,且与唐氏综合征有关。

病例报告

描述了一名患有唐氏综合征的儿科女性患者,其手指远端出现伴有甲营养不良和甲下角化过度的结痂性白色斑块。基于这些发现,考虑诊断为Hallopeau连续性肢端皮炎。进行了钻孔活检,确诊为CS。她接受了口服伊维菌素的全身治疗、润肤霜和0.1%地奈德的局部治疗。治疗结束两周后观察到明显的临床改善。

结论

CS是一种在免疫功能低下患者和唐氏综合征患者中常见的疥疮变种,容易与伴有异常表皮角化的炎症性疾病相混淆。由于手指局部受累和甲营养不良,该病例被认为是该病的非典型表现。组织病理学研究对于确诊和排除鉴别诊断是必要的。

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