Nagsuk Phillips, Moore Rachel, Lopez Lisa
Baylor Scott & White Health/Texas A&M College of Medicine.
Dermatol Online J. 2015 Aug 15;21(8):13030/qt4kc74256.
Crusted (Norwegian) scabies is a severe manifestation of the contagious skin infection caused by Sarcoptes scabiei. Crusted scabies has been well described in patients with known immunocompromised states. Treatment may be complicated by delayed diagnosis and/or inadequate treatment. This infection may not rank highly on one's differential diagnosis in the absence of an immunocompromised state, highlighting the uniqueness of the case being presented. Several papers describe immunocompromised children with Down syndrome who are infected with crusted scabies. We present a case of infection in an adult with Down syndrome without evidence of an immunocompromised state.
Our patient came to us with a 13-month history of progressively worsening symptoms, the last 4-6 weeks of that time period being most dramatic, despite various treatments. We performed tissue biopsy, culture, and laboratory evaluations, which revealed numerous mites and bacterial superinfection.
Crusted scabies infection may occur in adult age individuals with Down syndrome regardless of immune status, leading us to encourage practitioners to consider this condition when presented with patients of this population. We also highlight the need for further exploration of disease prevalence in this patient population.
结痂性(挪威型)疥疮是由疥螨引起的传染性皮肤感染的一种严重表现形式。结痂性疥疮在已知免疫功能低下状态的患者中已有充分描述。治疗可能因诊断延迟和/或治疗不充分而变得复杂。在没有免疫功能低下状态的情况下,这种感染在鉴别诊断中可能不占重要地位,凸显了本病例的独特性。几篇论文描述了患有结痂性疥疮的免疫功能低下的唐氏综合征儿童。我们报告一例无免疫功能低下证据的成年唐氏综合征患者感染疥疮的病例。
我们的患者有13个月逐渐加重的症状病史,尽管接受了各种治疗,但在该时间段的最后4 - 6周症状最为严重。我们进行了组织活检、培养和实验室评估,结果显示有大量螨虫和细菌二重感染。
无论免疫状态如何,成年唐氏综合征患者都可能发生结痂性疥疮感染,这促使我们鼓励从业者在面对该人群患者时考虑这种情况。我们还强调需要进一步探索该患者群体中的疾病患病率。