对埃及肥胖儿童和青少年进行血管紧张素转换酶基因插入/缺失（I/D）多态性筛查。
Screening of Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme gene.
作者信息
El-Kabbany Zeinab A, Hamza Rasha T, Shinkar Dina M, Kamal Tarek M, Abdelmageed Reham I, Said Mina S, Abdel-Hamid Mennatullah I
机构信息
Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Human Medical Genetics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
出版信息
Int J Pediatr Adolesc Med. 2019 Mar;6(1):21-24. doi: 10.1016/j.ijpam.2019.02.008. Epub 2019 Feb 25.
BACKGROUND
/aims: The role of angiotensin-converting enzyme (ACE) gene polymorphism in the development of obesity and hypertension in children has not been widely studied. We aimed to screen Egyptian obese children and adolescents for insertion/deletion (I/D) polymorphism in the ACE gene.
METHODS
One hundred forty-two children and adolescents were included (70 with simple obesity and 72 controls). Blood pressure was measured, and anthropometric parameters were assessed in all included children and adolescents. Fasting lipid profile, fasting glucose, and insulin were measured. DNA extraction and ACE I/D polymorphism genotyping were also performed.
RESULTS
Obese children had a higher frequency of DD genotype (30% in obese versus 11.1% in controls, = .01) and D alleles (61.8% in obese versus 48.6% in controls, = .01). Obese children with hypertension and prehypertension had higher frequency of DD genotype than II genotype and higher D alleles than I alleles. DD genotype and D allele were independently associated with hypertension (OR: 9.86 and 11.57, respectively, < .001), while dyslipidemia and insulin resistance were not associated with the ACE I/D gene polymorphism.
CONCLUSION
DD genotype and D-allele of the ACE gene polymorphism were associated with obesity and with hypertension and pre-hypertension in Egyptian children.
背景
/目的：血管紧张素转换酶（ACE）基因多态性在儿童肥胖和高血压发生发展中的作用尚未得到广泛研究。我们旨在筛查埃及肥胖儿童和青少年ACE基因的插入/缺失（I/D）多态性。
方法
纳入142名儿童和青少年（70例单纯性肥胖者和72例对照者）。测量所有纳入儿童和青少年的血压，并评估人体测量参数。测量空腹血脂、空腹血糖和胰岛素。还进行了DNA提取和ACE I/D多态性基因分型。
结果
肥胖儿童的DD基因型频率较高（肥胖组为30%，对照组为11.1%，P = 0.01），D等位基因频率也较高（肥胖组为61.8%，对照组为48.6%，P = 0.01）。患有高血压和高血压前期的肥胖儿童的DD基因型频率高于II基因型，D等位基因频率高于I等位基因。DD基因型和D等位基因与高血压独立相关（OR分别为9.86和11.57，P < 0.001），而血脂异常和胰岛素抵抗与ACE I/D基因多态性无关。
结论
ACE基因多态性的DD基因型和D等位基因与埃及儿童的肥胖、高血压和高血压前期有关。
Zotero 插件