运用激发-发射矩阵荧光结合平行因子分析法对苯丙胺类非法药物进行快速简易分析。

Xu Buyi, Ye Yi, Liao Linchuan

Sichuan Provincial Department of Public Security, Chengdu, China.

Department of Forensic Toxicological Analysis, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China.

Forensic Sci Res. 2017 Jul 24;4(2):179-187. doi: 10.1080/20961790.2017.1349600. eCollection 2019.

Nowadays, the abuse of illegal drugs has been an increasingly grim problem in the world. Excitation-emission matrix fluorescence combined with parallel factor analysis was used to make a quantitative analysis of the simulated amphetamine-type illegal drugs. Satisfactory results were achieved for simultaneous determination of methamphetamine (MAM) and 3, 4-methylenedioxymethamphetamine (MDMA) in the presence of adulterants. The average recoveries were (99.8 ± 0.6)% and (101.6 ± 5.7)% for MAM and MDMA, respectively. Figures of merit including root-mean-square error of calibration and prediction, sensitivity and selectivity were investigated to evaluate the performance of the proposed method. The limits of detection were 0.054 and 0.002 1 μg/mL for MAM and MDMA, respectively.

如今，非法药物滥用已成为全球一个日益严峻的问题。采用激发发射矩阵荧光结合平行因子分析对模拟苯丙胺类非法药物进行定量分析。在存在掺杂物的情况下，同时测定甲基苯丙胺（MAM）和3,4-亚甲基二氧基甲基苯丙胺（MDMA）取得了令人满意的结果。MAM和MDMA的平均回收率分别为（99.8±0.6）%和（101.6±5.7）%。研究了包括校准和预测的均方根误差、灵敏度和选择性等性能指标，以评估所提出方法的性能。MAM和MDMA的检测限分别为0.054和0.002 1μg/mL。