一种与泥蜂幼虫有关的 菌所产生的三联苯和放线菌素。
-Terphenyls and actinomycins from a sp. associated with the larva of mud dauber wasp.
机构信息
College of Marine Science, Shandong University at Weihai, Weihai, People's Republic of China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
出版信息
Nat Prod Res. 2021 Jun;35(11):1869-1873. doi: 10.1080/14786419.2019.1639177. Epub 2019 Jul 15.
In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural -terphenyl glycosides, strepantibin D () and strepantibin E (), along with terferol (), actinomycin D (), actinomycin V () and actinomycin V (), were identified from the fermentation medium of a sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D (), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural -terphenyl in this research. Strepantibin D () and terferol () showed medium cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231 and BT-474. Actinomycins (-), especially actinomycin V (), displayed remarkable cytotoxicity against breast cancer cells, with IC values ranging from 0.83 nM to 369.90 nM.
在从与放线菌相关的昆虫中寻找细胞毒性代谢产物的过程中，从一种 放线菌的发酵培养基中分离得到了两种新的天然联苯糖苷，即链霉菌素 D () 和链霉菌素 E ()，以及萜醇 (), 放线菌素 D (), 放线菌素 V () 和放线菌素 V ()。该放线菌是从泥蜂幼虫体中获得的。链霉菌素 D () 以前被报道为萜烯 A 的合成衍生物，在本研究中首次被分离为一种天然联苯。链霉菌素 D () 和萜醇 () 对乳腺癌细胞 MCF-7、MDA-MB-231 和 BT-474 表现出中等细胞毒性活性。放线菌素 (-)，特别是放线菌素 V ()，对乳腺癌细胞表现出显著的细胞毒性，IC 值范围从 0.83 nM 到 369.90 nM。
Zotero 插件