• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型放线菌素 A 和 B，一种具有 5H-噁唑并[4,5-b]吩嗪发色团的天然放线菌素，来源于海洋来源的链霉菌 IMB094。

Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094.

机构信息

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

出版信息

Sci Rep. 2017 Jun 15;7(1):3591. doi: 10.1038/s41598-017-03769-8.

DOI:10.1038/s41598-017-03769-8
PMID:28620204
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5472614/
Abstract

Neo-actinomycins A and B (1 and 2), two new natural actinomycins featuring an unprecedented tetracyclic 5H-oxazolo[4,5-b]phenoxazine chromophore, were isolated from the marine-derived actinomycete Streptomyces sp. IMB094. Their structures were elucidated by spectroscopic analyses. The presence of this ring system was proposed to originate from a condensation between actinomycin D (3) with α-ketoglutarate and pyruvate, respectively. Compound 1 showed potent cytotoxic activities against human cancer HCT116 and A549 cell lines in the nanomolar range (IC: 38.7 and 65.8 nM, respectively) and moderate antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) strains.

摘要

新型放线菌素 A 和 B（1 和 2）是从海洋来源放线菌 Streptomyces sp. IMB094 中分离得到的两种具有前所未有四环 5H-噁唑并[4,5-b]吩嗪发色团的新型天然放线菌素。通过光谱分析阐明了它们的结构。该环系的存在被认为是分别由放线菌素 D（3）与α-酮戊二酸和丙酮酸缩合而成。化合物 1 对人癌细胞 HCT116 和 A549 细胞系表现出强烈的细胞毒性，其 IC50 值分别为 38.7 和 65.8 nM，对耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE）菌株也具有中等的抗菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/05cf2f1684c8/41598_2017_3769_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/a20e71ca57a5/41598_2017_3769_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/54f50aa51d18/41598_2017_3769_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/05cf2f1684c8/41598_2017_3769_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/a20e71ca57a5/41598_2017_3769_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/54f50aa51d18/41598_2017_3769_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/813e/5472614/05cf2f1684c8/41598_2017_3769_Fig3_HTML.jpg

相似文献

1
Neo-actinomycins A and B, natural actinomycins bearing the 5H-oxazolo[4,5-b]phenoxazine chromophore, from the marine-derived Streptomyces sp. IMB094.新型放线菌素 A 和 B，一种具有 5H-噁唑并[4,5-b]吩嗪发色团的天然放线菌素，来源于海洋来源的链霉菌 IMB094。
Sci Rep. 2017 Jun 15;7(1):3591. doi: 10.1038/s41598-017-03769-8.
2
Purification and characterization of actinomycins from Streptomyces strain M7 active against methicillin resistant Staphylococcus aureus and vancomycin resistant Enterococcus.从抗甲氧西林金黄色葡萄球菌和万古霉素耐药肠球菌的链霉菌 M7 菌株中分离和鉴定抗微生物素。
BMC Microbiol. 2019 Feb 19;19(1):44. doi: 10.1186/s12866-019-1405-y.
3
Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T.来自链霉菌 XZHG99T 的细胞毒性抗生素安格鲁霉素和放线菌素。
J Antibiot (Tokyo). 2018 Nov;71(12):1018-1024. doi: 10.1038/s41429-018-0096-1. Epub 2018 Aug 29.
4
Asp-containing actinomycin and tetracyclic chromophoric analogues from the sp. strain S22.来自sp.菌株S22的含天冬氨酸的放线菌素和四环发色类似物。
Org Biomol Chem. 2023 Feb 22;21(8):1737-1743. doi: 10.1039/d2ob02247h.
5
Antibacterial and Cytotoxic Actinomycins Y-Y and Zp from Streptomyces sp. Strain Gö-GS12.链霉菌属菌株Gö-GS12产生的抗菌及细胞毒性放线菌素Y-Y和Zp
J Nat Prod. 2016 Oct 28;79(10):2731-2739. doi: 10.1021/acs.jnatprod.6b00742. Epub 2016 Oct 13.
6
Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399.海洋来源的链霉菌 SCSIO 41399 中具有细胞毒性的蒽环类抗生素和抗菌替拉霉素类似物。
J Antibiot (Tokyo). 2019 Jan;72(1):45-49. doi: 10.1038/s41429-018-0103-6. Epub 2018 Sep 26.
7
Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces.马尔米霉素A和B，源自一种与链霉菌属相关的海洋沉积物放线菌的具有细胞毒性的五环C-糖苷。
J Nat Prod. 2007 Sep;70(9):1406-9. doi: 10.1021/np060621r. Epub 2007 Sep 11.
8
First Y-type actinomycins from Streptomyces with divergent structure-activity relationships for antibacterial and cytotoxic properties.首次从链霉菌中分离出具有不同抗菌和细胞毒性构效关系的Y型放线菌素。
Org Biomol Chem. 2009 Feb 7;7(3):444-50. doi: 10.1039/b815689a. Epub 2008 Dec 11.
9
New Metabolites and Bioactive Actinomycins from Marine-Derived Streptomyces sp. ZZ338.来自海洋来源链霉菌ZZ338的新代谢产物及生物活性放线菌素
Mar Drugs. 2016 Oct 11;14(10):181. doi: 10.3390/md14100181.
10
A new actinomycin Z analogue with an additional oxygen bridge between chromophore and β-depsipentapeptide from Streptomyces sp. KIB-H714.一种来自链霉菌属KIB-H714的新放线菌素Z类似物，其发色团与β-去甲戊肽之间有一个额外的氧桥。
Nat Prod Res. 2019 Jan;33(2):219-225. doi: 10.1080/14786419.2018.1443097. Epub 2018 Mar 2.

引用本文的文献

1
Salt-Adapted Microorganisms: A Promising Resource for Novel Anti-Cancer Drug Discovery.盐适应性微生物：新型抗癌药物发现的一个有前景的资源。
Mar Drugs. 2025 Jul 24;23(8):296. doi: 10.3390/md23080296.
2
The role of Streptomyces to achieve the United Nations sustainable development goals. Burning questions in searching for new compounds.链霉菌在实现联合国可持续发展目标中的作用。寻找新化合物的紧迫问题。
Microb Biotechnol. 2024 Aug;17(8):e14541. doi: 10.1111/1751-7915.14541.
3
Marine -Derived Novel Alkaloids Discovered in the Past Decade.

本文引用的文献

1
Antibacterial and Cytotoxic Actinomycins Y-Y and Zp from Streptomyces sp. Strain Gö-GS12.链霉菌属菌株Gö-GS12产生的抗菌及细胞毒性放线菌素Y-Y和Zp
J Nat Prod. 2016 Oct 28;79(10):2731-2739. doi: 10.1021/acs.jnatprod.6b00742. Epub 2016 Oct 13.
2
Saccharothrixones A-D, Tetracenomycin-Type Polyketides from the Marine-Derived Actinomycete Saccharothrix sp. 10-10.糖丝菌素A-D，源自海洋放线菌糖丝菌属10-10的蒽环类聚酮化合物。
J Nat Prod. 2015 Sep 25;78(9):2260-5. doi: 10.1021/acs.jnatprod.5b00577. Epub 2015 Aug 28.
3
Identification of elaiophylin derivatives from the marine-derived actinomycete Streptomyces sp. 7-145 using PCR-based screening.
过去十年中发现的海洋来源新型生物碱。
Mar Drugs. 2024 Jan 22;22(1):51. doi: 10.3390/md22010051.
4
Genome mining of actinomycin shunt products from sp. YINM00002.来自YINM00002菌株的放线菌素分流产物的基因组挖掘
RSC Adv. 2023 Dec 12;13(51):36200-36208. doi: 10.1039/d3ra07277k. eCollection 2023 Dec 8.
5
Probiotics and Their Bioproducts: A Promising Approach for Targeting Methicillin-Resistant and Vancomycin-Resistant .益生菌及其生物制品：一种针对耐甲氧西林和耐万古霉素的有前景的方法
Microorganisms. 2023 Sep 25;11(10):2393. doi: 10.3390/microorganisms11102393.
6
and evaluations of actinomycin Xand actinomycin D as potent anti-tuberculosis agents.并评估更生霉素 X 和更生霉素 D 作为有效的抗结核药物。
PeerJ. 2023 Mar 8;11:e14502. doi: 10.7717/peerj.14502. eCollection 2023.
7
Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic sp.来自一种内生菌的细胞毒性六肽缩酚酸肽和抗冠状病毒4-羟基-2-吡啶酮
Front Chem. 2023 Jan 12;10:1106869. doi: 10.3389/fchem.2022.1106869. eCollection 2022.
8
Secondary Metabolites from Marine-Derived Bacteria with Antibiotic and Antibiofilm Activities against Drug-Resistant Pathogens.海洋来源细菌的次生代谢产物具有抗耐药病原菌的抗生素和抗生物膜活性。
Mar Drugs. 2023 Jan 12;21(1):50. doi: 10.3390/md21010050.
9
Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.放线菌来源的天然产物作为抗结直肠癌新疗法的潜在来源：综述
Front Pharmacol. 2022 Jul 11;13:929161. doi: 10.3389/fphar.2022.929161. eCollection 2022.
10
Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease-A Systematic Literature Review.海洋放线菌——治疗寻常痤疮的抗菌代谢产物新来源——系统文献综述
Antibiotics (Basel). 2022 Jul 18;11(7):965. doi: 10.3390/antibiotics11070965.
利用基于 PCR 的筛选技术从海洋来源放线菌 Streptomyces sp. 7-145 中鉴定出榄香醇衍生物。
J Nat Prod. 2013 Nov 22;76(11):2153-7. doi: 10.1021/np4006794. Epub 2013 Oct 28.
4
Occurrence and biosynthesis of C-demethylactinomycins in actinomycin-producing Streptomyces chrysomallus and Streptomyces parvulus.金黄链霉菌和小单孢菌中产放线菌素过程中 C-去甲基放线菌素的产生和生物合成。
J Antibiot (Tokyo). 2013 Apr;66(4):211-8. doi: 10.1038/ja.2012.120. Epub 2013 Feb 20.
5
TCA cycle involved enzymes SucA and Kgd, as well as MenD: efficient biocatalysts for asymmetric C-C bond formation.三羧酸循环涉及酶 SucA 和 Kgd，以及 MenD：用于不对称 C-C 键形成的高效生物催化剂。
Org Lett. 2013 Feb 1;15(3):452-5. doi: 10.1021/ol3031186. Epub 2013 Jan 14.
6
Selecting multimodal therapy for rhabdomyosarcoma.选择多模式疗法治疗横纹肌肉瘤。
Expert Rev Anticancer Ther. 2010 Aug;10(8):1285-301. doi: 10.1586/era.10.96.
7
Novel molecular mechanism for actinomycin D activity as an oncogenic promoter G-quadruplex binder.放线菌素D作为致癌启动子G-四链体结合剂的新型分子机制。
Biochemistry. 2009 Aug 11;48(31):7392-8. doi: 10.1021/bi9006836.
8
First Y-type actinomycins from Streptomyces with divergent structure-activity relationships for antibacterial and cytotoxic properties.首次从链霉菌中分离出具有不同抗菌和细胞毒性构效关系的Y型放线菌素。
Org Biomol Chem. 2009 Feb 7;7(3):444-50. doi: 10.1039/b815689a. Epub 2008 Dec 11.
9
Actinomycins with altered threonine units in the beta-peptidolactone.在β-肽内酯中苏氨酸单元发生改变的放线菌素。
J Nat Prod. 2006 Aug;69(8):1153-7. doi: 10.1021/np060063g.
10
Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora".马瑞诺霉素A - D，一种来自最近发现的“海孢子菌属”海洋放线菌的新型结构类别的抗肿瘤抗生素。
J Am Chem Soc. 2006 Feb 8;128(5):1622-32. doi: 10.1021/ja0558948.