脱氧核糖核苷对恶性人T细胞系毒性增强的生化基础。
Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.
作者信息
Carson D A, Kaye J, Matsumoto S, Seegmiller J E, Thompson L
出版信息
Proc Natl Acad Sci U S A. 1979 May;76(5):2430-3. doi: 10.1073/pnas.76.5.2430.
Abstract
Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.
摘要
人类恶性T细胞系具有高水平的脱氧核糖核苷磷酸化活性和低水平的脱氧核糖核苷酸去磷酸化活性。当与脱氧腺苷或胸苷一起孵育时，恶性T细胞系会分别迅速积累有毒浓度的dATP和dTTP。这种脱氧核糖核苷酸代谢的异常模式使恶性T细胞特别容易受到脱氧核糖核苷及相关类似物的毒性作用影响。
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