Neer E J, Clapham D E
Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts 02115.
Nature. 1988 May 12;333(6169):129-34. doi: 10.1038/333129a0.
A family of proteins called G proteins couples cell surface receptors to a variety of enzymes and ion channels. Since many cells contain several very similar G proteins, an important question is how signals remain specific as they cross the cell membrane.
一类被称为G蛋白的蛋白质家族,将细胞表面受体与多种酶和离子通道连接起来。由于许多细胞含有几种非常相似的G蛋白,一个重要的问题是,当信号穿过细胞膜时,它们是如何保持特异性的。