Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas.
Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, Texas.
J Clin Endocrinol Metab. 2019 Nov 1;104(11):4990-4997. doi: 10.1210/jc.2019-01132.
The association between hypothyroidism and sleep apnea (SA) has been studied, but results are conflicting and based mostly on small studies.
To determine whether there is a positive association between hypothyroidism and SA in the US population.
Cross-sectional study.
US National Health and Nutrition Examination Survey, 2007-2008.
We included all subjects ≥18 years old who met inclusion criteria. Participants not on antithyroid medication with a TSH >5.6 mIU/L and those on thyroid hormone replacement regardless of TSH were categorized as hypothyroid. Participants not on thyroid hormone replacement or antithyroid medication who had a TSH ≥0.34 and ≤5.6 mIU/L were categorized as euthyroid. The diagnosis of SA was based on participants' response when asked whether they had been diagnosed with SA by their doctors.
Multivariate logistic regression analyses were performed to determine the association between hypothyroidism and SA.
A total of 5515 adults were included for data analysis. The prevalence of hypothyroidism and hyperthyroidism was calculated at 9.47% and 1.19%, respectively. Multivariate logistic regression analysis adjusted for demographics, health care access, body mass index, socioeconomic factors, alcohol use, smoking, and other comorbidities demonstrated a significant association between hypothyroidism and SA (OR = 1.88, 95% CI, 1.24 to 2.84, P < 0.01).
Hypothyroidism is associated with SA after adjustment for potential confounding variables.
甲状腺功能减退症与睡眠呼吸暂停（SA）之间的关联已经过研究，但结果存在冲突，且主要基于小型研究。
在美国人群中确定甲状腺功能减退症与 SA 之间是否存在正相关。
横断面研究。
美国国家健康和营养调查，2007-2008 年。
我们纳入了符合纳入标准的所有≥18 岁的受试者。未服用抗甲状腺药物且 TSH＞5.6mIU/L 的患者以及无论 TSH 如何均接受甲状腺激素替代治疗的患者被归类为甲状腺功能减退症。未接受甲状腺激素替代治疗或抗甲状腺药物治疗且 TSH≥0.34 且≤5.6mIU/L 的患者被归类为甲状腺功能正常。SA 的诊断基于参与者是否被医生诊断为 SA 的回答。
进行多变量逻辑回归分析以确定甲状腺功能减退症与 SA 之间的关联。
共纳入 5515 名成年人进行数据分析。甲状腺功能减退症和甲状腺功能亢进症的患病率分别计算为 9.47%和 1.19%。多变量逻辑回归分析调整了人口统计学、医疗保健机会、体重指数、社会经济因素、酒精使用、吸烟和其他合并症，结果表明甲状腺功能减退症与 SA 之间存在显著关联（OR=1.88，95%CI，1.24 至 2.84，P＜0.01）。
在调整潜在混杂变量后，甲状腺功能减退症与 SA 相关。
Zotero 插件