Zhou Pinyi, Li Hongmei, Qiu Jingman, Ye Jing, Guo Jingyu, Yao Yun, Li Hongyan, Shi Yanfen, Duan Yufan, Lv Yunhui
Department of Sleep Medicine, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650500, People's Republic of China.
Department of Neurology, The Affiliated Hospital of Kunming University of Science and Technology, The First People's Hospital of Yunnan Province, Kunming, 650500, People's Republic of China.
Nat Sci Sleep. 2025 Jun 23;17:1467-1475. doi: 10.2147/NSS.S515819. eCollection 2025.
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is closely associated with hypothyroidism. This study aimed to evaluate the prevalence and correlation of hypothyroidism in patients with OSAHS.
This investigation included a cohort of 1693 patients newly diagnosed with OSAHS, all of whom underwent polysomnography and thyroid function assessments.
The study cohort comprised 1693 OSAHS patients (60.4% male). No significant differences in thyroid-stimulating hormone (TSH) or free thyroxine (FT4) levels were observed across OSAHS severity groups ( = 0.670 and = 0.307). Notably, patients with overt hypothyroidism demonstrated significantly lower lowest oxygen saturation (LSpO) levels than their euthyroid counterparts ( = 0.035). The analysis did not reveal any significant correlations between TSH/FT4 levels and the apnea-hypopnea index, mean oxygen saturation (MSpO₂), or LSpO₂. Nevertheless, TSH levels were positively correlated with female sex and age ( = 0.001), while no correlation was found with body mass index. After controlling for sex and age, TSH was positively correlated with apnea-hypopnea index ( = 0.002) and negatively correlated with both MSpO₂ and LSpO₂ ( = 0.001). In contrast, FT4 levels exhibited a negative correlation with apnea-hypopnea index ( = 0.016) and positive correlations with MSpO₂ and LSpO₂ ( = 0.030 and = 0.018). The overall prevalence rates of hypothyroidism and overt hypothyroidism within the study population were determined to be 13.7% and 3.8%, respectively, with no significant differences observed across the severity categories of OSAHS ( = 0.166 and = 0.193). Subclinical hypothyroidism was identified in 9.9% of the patients, with a notably lower prevalence in those with severe OSAHS compared to those with milder forms of the condition ( = 0.004).
In patients with OSAHS, 13.7% had hypothyroidism, with 3.8% being overt hypothyroidism and 9.9% being subclinical hypothyroidism. Thyroid function parameters are associated with the severity of OSAHS and are influenced by sex and age.
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与甲状腺功能减退密切相关。本研究旨在评估OSAHS患者甲状腺功能减退的患病率及其相关性。
本调查纳入了1693例新诊断为OSAHS的患者，所有患者均接受了多导睡眠图检查和甲状腺功能评估。
研究队列包括1693例OSAHS患者（男性占60.4%）。在不同OSAHS严重程度组中，促甲状腺激素（TSH）或游离甲状腺素（FT4）水平未观察到显著差异（P = 0.670和P = 0.307）。值得注意的是，明显甲状腺功能减退的患者其最低血氧饱和度（LSpO₂）水平显著低于甲状腺功能正常的患者（P = 0.035）。分析未发现TSH/FT4水平与呼吸暂停低通气指数、平均血氧饱和度（MSpO₂）或LSpO₂之间存在任何显著相关性。然而，TSH水平与女性性别和年龄呈正相关（P = 0.001），而与体重指数无相关性。在控制性别和年龄后，TSH与呼吸暂停低通气指数呈正相关（P = 0.002），与MSpO₂和LSpO₂均呈负相关（P = 0.001）。相比之下，FT4水平与呼吸暂停低通气指数呈负相关（P = 0.016），与MSpO₂和LSpO₂呈正相关（P = 0.030和P = 0.018）。研究人群中甲状腺功能减退和明显甲状腺功能减退的总体患病率分别确定为13.7%和3.8%，在OSAHS的不同严重程度类别中未观察到显著差异（P = 0.166和P = 0.193）。9.9%的患者被诊断为亚临床甲状腺功能减退，与病情较轻的患者相比，重度OSAHS患者的患病率明显较低（P = 0.004）。
在OSAHS患者中，13.7%患有甲状腺功能减退，其中3.8%为明显甲状腺功能减退，9.9%为亚临床甲状腺功能减退。甲状腺功能参数与OSAHS的严重程度相关，并受性别和年龄影响。
