Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark.
Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Denmark.
Pediatr Infect Dis J. 2019 Nov;38(11):e307-e309. doi: 10.1097/INF.0000000000002416.
We systematically retested children with borderline-positive quantiferon (0.35-0.99 IU/mL) during the period 2015-2019. Among 647 tests, 27 (4%) were positive (>0.35 IU/mL). Borderline-positive quantiferon accounted for 10 of 27 (37%) positive tests. When retested, 9 of 10 (90%) were negative. Children younger than 5 years had negative tuberculin skin tests. Thus, we found high test variability in the borderline range and, in some children, high suspicion of false positive tests.
我们在 2015 年至 2019 年期间系统地重新测试了定量干扰素边界阳性（0.35-0.99 IU/mL）的儿童。在 647 次检测中，有 27 次（4%）为阳性（>0.35 IU/mL）。在 27 次阳性检测中，边界阳性干扰素占 10 次（37%）。重新检测时，10 次中有 9 次（90%）为阴性。5 岁以下儿童结核菌素皮肤试验阴性。因此，我们发现边界范围内的检测变异性很高，在一些儿童中，存在高度怀疑的假阳性检测。
