花生四烯酸与甲巯咪唑被前列腺素内过氧化物合成酶的共氧化作用。
Co-oxidation of arachidonic acid and methimazole by prostaglandin endoperoxide synthetase.
作者信息
Conn I G, Ferguson M M, Skellern G G, Sweeney D, Steer S T
机构信息
Department of Surgery, University of Glasgow, Western Infirmary, UK.
出版信息
Pharmacology. 1988;36(3):145-50. doi: 10.1159/000138377.
PMID:3130644
Abstract
The thiocarbamide methimazole stimulated O2 utilisation when added to reaction mixtures containing ram seminal vesicle microsomes (prostaglandin endoperoxide synthetase preparation) and arachidonic acid. This stimulation increased with increasing methimazole concentrations, as did the production of prostaglandin E. 2-[14C]Methimazole was co-oxidized to 1-methyl-2-[14C]imidazole.
摘要
当将硫脲类药物甲巯咪唑添加到含有公羊精囊微粒体（前列腺素内过氧化物合成酶制剂）和花生四烯酸的反应混合物中时，它会刺激氧气的利用。随着甲巯咪唑浓度的增加，这种刺激作用增强，前列腺素E的生成也随之增加。2-[¹⁴C]甲巯咪唑被共氧化为1-甲基-2-[¹⁴C]咪唑。
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