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光动力疗法治疗皮肤利什曼病有效:病例报告。

Effective treatment with photodynamic therapy of cutaneous leishmaniasis: A case report.

机构信息

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

出版信息

Dermatol Ther. 2019 Sep;32(5):e13022. doi: 10.1111/dth.13022. Epub 2019 Jul 28.

Abstract

Leishmaniasis is a vector borne disease transmitted by phlebotomine sandflies. Cutaneous leishmaniasis (CL) predominantly causes skin ulcers but may disseminate. CL may present a therapeutic challenge. The present study reports the case of a 15-year old boy with CL consisting of a single, ulcer on the leg, resistant to pentavalent antimony, oral fluconazole and topical ketoconazole therapy. Repeated photodynamic therapy using aminolevulinic acid resulted in complete healing of the ulcer, suggesting utility of this approach in resistant cases of CL.

摘要

利什曼病是一种由白蛉传播的虫媒病。皮肤利什曼病(CL)主要导致皮肤溃疡,但也可能扩散。CL 可能具有治疗挑战性。本研究报告了一例 15 岁男孩的 CL 病例,其表现为腿部单一溃疡,对五价锑、口服氟康唑和局部酮康唑治疗具有耐药性。重复使用氨基酮戊酸的光动力疗法导致溃疡完全愈合,表明该方法在 CL 的耐药病例中具有应用价值。

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