光疗和光学波导在感染治疗中的应用。
Phototherapy and optical waveguides for the treatment of infection.
机构信息
Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA; Academy of Orthopedics, Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province 510280, China.
出版信息
Adv Drug Deliv Rev. 2021 Dec;179:114036. doi: 10.1016/j.addr.2021.114036. Epub 2021 Nov 3.
With rapid emergence of multi-drug resistant microbes, it is imperative to seek alternative means for infection control. Optical waveguides are an auspicious delivery method for precise administration of phototherapy. Studies have shown that phototherapy is promising in fighting against a myriad of infectious pathogens (i.e. viruses, bacteria, fungi, and protozoa) including biofilm-forming species and drug-resistant strains while evading treatment resistance. When administered via optical waveguides, phototherapy can treat both superficial and deep-tissue infections while minimizing off-site effects that afflict conventional phototherapy and pharmacotherapy. Despite great therapeutic potential, exact mechanisms, materials, and fabrication designs to optimize this promising treatment option are underexplored. This review outlines principles and applications of phototherapy and optical waveguides for infection control. Research advances, challenges, and outlook regarding this delivery system are rigorously discussed in a hope to inspire future developments of optical waveguide-mediated phototherapy for the management of infection and beyond.
随着多药耐药微生物的迅速出现，寻找感染控制的替代方法势在必行。光波导是精确光疗给药的一种有前途的方法。研究表明，光疗在对抗包括生物膜形成物种和耐药菌株在内的多种感染病原体（即病毒、细菌、真菌和原生动物）方面具有广阔的前景，同时避免了治疗耐药性。通过光波导给药时，光疗可以治疗浅表和深部组织感染，同时最大限度地减少传统光疗和药物治疗的副作用。尽管具有巨大的治疗潜力，但确切的机制、材料和制造设计来优化这种有前途的治疗选择仍未得到充分探索。本综述概述了光疗和光波导在感染控制方面的原理和应用。本文严格讨论了该输送系统的研究进展、挑战和展望，以期为光波导介导的光疗在感染管理及其他领域的发展提供启示。
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