物质使用障碍的表观遗传药理学治疗。
Epigenetic pharmacotherapy for substance use disorder.
机构信息
University of Connecticut, Department of Pharmaceutical Sciences, 69 N. Eagleville Road, Storrs, CT 06269, United States.
出版信息
Biochem Pharmacol. 2019 Oct;168:269-274. doi: 10.1016/j.bcp.2019.07.012. Epub 2019 Jul 12.
Abstract
Identifying novel therapeutics for the treatment of substance use disorder (SUD) is an area of intensive investigation. Prior strategies that have attempted to modify one or a few neurotransmitter receptors have had limited success, and currently there are no FDA-approved medications for the treatment of cocaine, methamphetamine, and marijuana use disorders. Because drugs of abuse are known to alter the expression of numerous genes in reward-related brain regions, epigenetic-based therapies have emerged as intriguing targets for therapeutic innovation. Here, I evaluate potential therapeutic approaches and challenges in targeting epigenetic factors for the treatment of SUD and highlight examples of promising strategies and future directions.
摘要
针对物质使用障碍（SUD）的治疗方法的研究一直以来都是热点。先前的策略试图通过改变一个或几个神经递质受体来实现，但收效甚微，目前FDA 也没有批准任何药物用于治疗可卡因、冰毒和大麻使用障碍。由于众所周知，滥用药物会改变与奖励相关的大脑区域中许多基因的表达，基于表观遗传的治疗方法已成为治疗创新的一个有趣目标。在这里，我评估了针对 SUD 治疗的表观遗传因素的潜在治疗方法和挑战，并强调了一些有前途的策略和未来方向。
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