偏头痛患者晕厥的危险因素和心理影响。

Risk factors and psychological impact of syncope in migraine patients.

机构信息

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Institute of Public Health, National Yang-Ming University, Taipei.

出版信息

Cephalalgia. 2019 Dec;39(14):1838-1846. doi: 10.1177/0333102419865253. Epub 2019 Jul 15.

DOI:10.1177/0333102419865253

PMID:31307206

Abstract

BACKGROUND

Migraine is associated with syncope. We investigated risk factors for syncope and burden of syncope in migraine patients.

METHODS

Participants were recruited from a headache clinic. All participants provided information on lifestyle, co-morbidity, syncope, headache and suicide, and completed the MIDAS and HADS questionnaires. Genetic data were available for a subset of participants. Risk of syncope in relation to participant's characteristics and migraine susceptibility loci, and risks of psychological disorders associated with syncope, were calculated using logistic regression.

RESULTS

Underweight, regular tea intake, diabetes mellitus, and migraine with aura were associated with increased syncope risks, with adjusted ORs of 1.76 (95% CI 1.03-3.03), 1.84 (95% CI 1.22-2.79), 4.70 (95% CI 1.58-13.95), and 1.78 (95% CI 1.03-3.10), respectively. Preliminary results showed that rs11172113 in LRP1 was associated with syncope risks. Comorbid syncope in migraine patients was associated with increased risks of depression (OR 1.95, 95% CI 1.18-3.22) and suicide attempt (OR 2.85, 95% CI 1.48-5.48).

CONCLUSION

Our study showed the potential roles of vascular risk factors in the association between migraine and syncope. Modifiable risk factors for syncope in patients with migraine include body mass index and tea intake. The debilitating psychological impact of co-morbid syncope in migraine patients warrants clinical attention of treating physicians.

摘要

背景

偏头痛与晕厥有关。我们研究了偏头痛患者晕厥的危险因素和晕厥负担。

方法

参与者从头痛诊所招募。所有参与者提供生活方式、合并症、晕厥、头痛和自杀的信息，并完成 MIDAS 和 HADS 问卷。一部分参与者提供了遗传数据。使用逻辑回归计算晕厥风险与参与者特征和偏头痛易感基因座的关系，以及与晕厥相关的心理障碍的风险。

结果

体重过轻、定期饮茶、糖尿病和有先兆偏头痛与晕厥风险增加相关，调整后的 OR 值分别为 1.76（95%CI 1.03-3.03）、1.84（95%CI 1.22-2.79）、4.70（95%CI 1.58-13.95）和 1.78（95%CI 1.03-3.10）。初步结果表明，LRP1 中的 rs11172113 与晕厥风险相关。偏头痛患者合并晕厥与抑郁（OR 1.95，95%CI 1.18-3.22）和自杀企图（OR 2.85，95%CI 1.48-5.48）的风险增加相关。