沙特阿拉伯阿西尔地区非霍奇金淋巴瘤的临床病理特征

The clinico-pathological profile of non-Hodgkin's lymphoma in Aseer region of Saudi Arabia.

作者信息

Alyahya Nawaf, Adiga Balkur, Alwadei Ali, Alshahrani Ghanem, Alyahya Fahad

机构信息

Department of Internal Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Department of Pathology, King Khalid University, Abha, Saudi Arabia.

出版信息

BMC Res Notes. 2019 Jul 15;12(1):418. doi: 10.1186/s13104-019-4447-1.

DOI:10.1186/s13104-019-4447-1

PMID:31307540

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6631452/

Abstract

OBJECTIVE

Non-Hodgkin lymphomas (NHL) are a group of neoplastic lymphoproliferative disorders, in which, its clinical spectrum, primary extra nodal variety, histopathology and Immunohistochemistry, remain lacking in Saudi Arabia. We aimed to assess the clinicopathologic patterns of NHL and the utility and diagnostic role of IHC immunophenotyping.

RESULTS

Patients > 60 years of age had the highest incidence of NHL; male: female ratio was 1.27:1. The incidence of NHL has shown a steady increase in the Aseer region from 2011 to 2014. Twenty-Five percent of our patients presented with advanced disease (Stage IV). A total of 52% of patients presented with constitutional symptoms, while 43% showed generalized lymphadenopathy. Nearly half of our patients (49%) had primary NHL of extra nodal variety, where the stomach was the most commonly involved organ (13 cases). Diffuse large B cell lymphoma was the most common subtype of NHL in our population (59%). Most patients (82%) were positive for CD20 surface marker, while 60% were positive for CD45.

摘要

目的

非霍奇金淋巴瘤（NHL）是一组肿瘤性淋巴细胞增殖性疾病，在沙特阿拉伯，其临床谱、原发性结外病变类型、组织病理学及免疫组织化学情况仍不明确。我们旨在评估NHL的临床病理模式以及免疫组化免疫表型分析的实用性和诊断作用。

结果

60岁以上患者的NHL发病率最高；男女比例为1.27:1。2011年至2014年，阿西尔地区的NHL发病率呈稳步上升趋势。我们的患者中有25%表现为晚期疾病（IV期）。共有52%的患者出现全身症状，而43%表现为全身淋巴结肿大。近一半的患者（49%）患有原发性结外NHL，其中胃是最常受累的器官（13例）。弥漫性大B细胞淋巴瘤是我们研究人群中最常见的NHL亚型（59%）。大多数患者（82%）的CD20表面标志物呈阳性，而60%的患者CD45呈阳性。