结核性葡萄膜炎的视觉及治疗效果：来自巴基斯坦一家转诊医院的前瞻性病例系列研究
Visual and treatment outcomes of tubercular uveitis: a prospective case series from a referral hospital in Pakistan.
作者信息
Ghauri Muhammad Ishaq, Iqbal Nousheen, Riaz Syeda Urooj, Irfan Muhammad, Kumar Ajeet, Mukarram Muhamad Shariq
机构信息
Department of Medicine, Jinnah Medical College Hospital, Karachi, Pakistan.
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan.
出版信息
BMC Res Notes. 2019 Jul 15;12(1):404. doi: 10.1186/s13104-019-4432-8.
OBJECTIVE
Pakistan is the fifth highest TB burden country. Tuberculous uveitis (TbU) is a form of extrapulmonary TB, that is not uncommon in high burden country but very limited data is available on its outcome. The aim of the study is to assess the outcome of TbU with anti-tuberculous treatment (ATT).
RESULTS
A prospective study was conducted at Jinnah Medical College Hospital (JMCH) Karachi, Pakistan from July to December 2017. Patients with suspected TbU were started on standard ATT chemotherapy for 12 months. Their response was assessed via slit lamp examination and visual acuity at 1, 3, 6 and 12 months of treatment. Forty patients with probable TbU were treated with ATT, mean age was 36 ± 3 years and 24 (60%) were females. Around 26 (65%) had Monteux test of 15 mm or more. History of TB contact was positive in 24 (60%) and 12 (30%) had previous history of TB. All patients complained for blurring of vision and floaters. Posterior uveitis seen in 36 (90%) of patients. Complete response achieved in 32 (80%) after ATT while 6 (14%) had changed in inflammation and 2 (6%) had no benefit.
目的
巴基斯坦是结核病负担第五高的国家。结核性葡萄膜炎（TbU）是肺外结核的一种形式，在高负担国家并不罕见，但关于其预后的数据非常有限。本研究的目的是评估抗结核治疗（ATT）对结核性葡萄膜炎的疗效。
结果
2017年7月至12月在巴基斯坦卡拉奇的真纳医学院医院（JMCH）进行了一项前瞻性研究。疑似结核性葡萄膜炎的患者开始接受为期12个月的标准抗结核化疗。在治疗的1、3、6和12个月时，通过裂隙灯检查和视力评估他们的反应。40例可能患有结核性葡萄膜炎的患者接受了抗结核治疗，平均年龄为36±3岁，24例（60%）为女性。约26例（65%）的结核菌素试验结果为15mm或更大。24例（60%）有结核接触史，12例（30%）有既往结核病史。所有患者均主诉视力模糊和有飞蚊症。36例（90%）患者出现后葡萄膜炎。抗结核治疗后32例（80%）完全缓解，6例（14%）炎症有变化，2例（6%）无改善。
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