Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan, 421001, China.
Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan, 421001, China; Department of Histology and Embryology, Human University of Chinese Medicine, Changsha, 410208, China.
Taiwan J Obstet Gynecol. 2019 Jul;58(4):447-453. doi: 10.1016/j.tjog.2019.05.003.
Polycystic ovary syndrome (PCOS) is widely accepted as the most common endocrine abnormality in women of childbearing age and may be accompanied by dyslipidemia, hyperandrogenism, hyperinsulinemia, oxidative stress and infertility. Dyslipidemia is now known to play an important role in the development of PCOS. Lipid abnormalities, including elevated low-density lipoprotein and triglyceride levels and reduced high-density lipoprotein levels, are often found in women with PCOS and play an important role in PCOS; therefore, we summarize the effect of lipid abnormalities on hyperandrogenism, insulin resistance, oxidative stress and infertility in PCOS and review the effects of common lipid-lowering drugs on patients with PCOS. The purpose of this article is to elucidate the mechanisms of lipid metabolism abnormalities in the development of PCOS.
多囊卵巢综合征（PCOS）被广泛认为是育龄妇女最常见的内分泌异常，可能伴有血脂异常、高雄激素血症、高胰岛素血症、氧化应激和不孕。目前已知血脂异常在 PCOS 的发生发展中起着重要作用。脂质异常，包括低密度脂蛋白和甘油三酯水平升高，高密度脂蛋白水平降低，常存在于 PCOS 患者中，并在 PCOS 中起重要作用；因此，我们总结了脂质异常对 PCOS 高雄激素血症、胰岛素抵抗、氧化应激和不孕的影响，并回顾了常见降脂药物对 PCOS 患者的影响。本文的目的是阐明脂质代谢异常在 PCOS 发病机制中的作用。
Zotero 插件