Bernichon Emilie, Espenel Sophie, Méry Benoite, Trone Jane-Chloé, Rehalia-Blanchard Amel, He Yuan Ming, Rancoule Chloé, Magné Nicolas
Institut de cancérologie Lucien-Neuwirth, département d'oncologie médicale, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.
Institut de cancérologie Lucien-Neuwirth, département de radiothérapie, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France; Laboratoire de radiobiologie cellulaire et moléculaire de Lyon Sud, CNRS UMR 5822, 165, chemin du grand Revoyet, BP 12, 69921 Oullins cedex, France.
Presse Med. 2019 Jul-Aug;48(7-8 Pt 1):756-766. doi: 10.1016/j.lpm.2019.05.019. Epub 2019 Jul 12.
Human oncogenic papillomaviruses (HPV) have an increasingly prominent role in the genesis of many cancers. The oncogenic mechanisms associated with HPV are now better known and make it possible to explain the etiopathogenesis of the association. HPV status is now sought for certain cancers and conditions both prognosis and management of patients. Preventive antiviral vaccination has become a real public health issue and aims to effectively reduce the prevalence of cervical, anal and oropharynx cancer, HPV-associated. However, vaccination against HPV still lags behind. The purpose of this review is to redefine the involvement of HPV in several cancers as well as current therapeutic challenges of HPV-related cancers, notably in term of prevention.
人类致癌性乳头瘤病毒（HPV）在许多癌症的发生中发挥着越来越突出的作用。与HPV相关的致癌机制如今已为人熟知，从而能够解释这种关联的病因发病机制。目前，对于某些癌症和病症，人们会检测HPV状态，这对患者的预后和治疗都有影响。预防性抗病毒疫苗接种已成为一个切实的公共卫生问题，旨在有效降低与HPV相关的宫颈癌、肛门癌和口咽癌的发病率。然而，HPV疫苗接种仍滞后。本综述的目的是重新界定HPV在几种癌症中的作用以及HPV相关癌症当前的治疗挑战，尤其是在预防方面。
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