Watler P K, Cholakis C H, Sefton M V
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada.
Biomaterials. 1988 Mar;9(2):150-4. doi: 10.1016/0142-9612(88)90114-7.
The effects of changes in the heparin-PVA formulation on the water content, compression modulus and molecular weight between cross-links of the resulting gel was determined. Molecular weight between cross-links was calculated directly from the compression modulus and the swelling ratio. Glutaraldehyde and MgCl2 displayed the effects expected of them as cross-linking agent and catalyst respectively. On the other hand, formaldehyde appeared to be a non-essential component since its absence had little effect on gel properties and its presence did not affect the water content as originally predicted. Understanding the effect of each formulation component on gel properties enables alteration of gel water content and hence permeability for special applications.
测定了肝素 - 聚乙烯醇配方的变化对所得凝胶的含水量、压缩模量和交联点间分子量的影响。交联点间分子量直接由压缩模量和溶胀率计算得出。戊二醛和氯化镁分别作为交联剂和催化剂表现出预期的效果。另一方面，甲醛似乎是一种非必需成分，因为其缺失对凝胶性质影响很小，且其存在并未如最初预测的那样影响含水量。了解每种配方成分对凝胶性质的影响有助于改变凝胶含水量，从而改变其在特殊应用中的渗透性。
