“CHOICES”：一个首字母缩略词，有助于明确非代谢性、非感染性急性中毒性白质脑病的潜在病因。
"CHOICES": An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy.
作者信息
Koksel Yasemin, Ozutemiz Can, Rykken Jeffrey, Ott Frederick, Cayci Zuzan, Oswood Mark, McKinney Alexander M
机构信息
Department of Radiology, Division of Neuroradiology, University of Minnesota Medical Center, Minneapolis, MN, USA.
Department of Radiology, Division of Neuroradiology Hennepin Healthcare Medical Center, Minneapolis, MN, USA.
出版信息
Eur J Radiol Open. 2019 Jun 28;6:243-257. doi: 10.1016/j.ejro.2019.06.005. eCollection 2019.
PURPOSE
To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them.
MATERIAL AND METHODS
Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded.
RESULT/DISCUSSION: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5).
CONCLUSION
The "CHOICES" acronym delineates various toxic etiologies of ATL.
目的
描述急性中毒性白质脑病（ATL）在扩散加权成像（DWI）磁共振成像（MRI）上的非代谢性、非感染性病因，并提供一个便于记忆的首字母缩写词。
材料与方法
回顾我们的图像存档与通信系统（PACS）档案，根据MRI报告和临床随访结果筛选出185例疑似ATL患者；排除感染性或代谢性病因。
结果/讨论：纳入研究的87例非感染性、非代谢性ATL患者的病因可用首字母缩写词“CHOICES”表示：化疗（“C”，n = 34）；海洛因所致（“H”，n = 6），阿片类类似物（“O”，n = 14）；免疫抑制剂（“I”，n = 11）或咪唑（n = 2）；可卡因（“C”，n = 1）；环境因素或乙醇滥用（“E”，n = 5），胼胝体病变（“S”，n = 9），以及“其他”（n = 5）。
结论
“CHOICES”这一首字母缩写词概括了ATL的各种中毒性病因。
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