Traub A I, McFaul P B, Sheridan B, Leslie H
Department of Midwifery & Gynaecology, Queens University, Belfast.
Clin Reprod Fertil. 1987 Aug;5(4):167-71.
Five patients with carefully defined polycystic ovarian disease (PCOS) were treated with pure follicle stimulating hormone (FSH) to induce ovulation. Serum levels of androstenedione and testosterone were measured daily and noted to rise dramatically, reaching a maximum at the time of ovulation. However, despite the rise in androgens, ovulation occurred in each case and three patients conceived. Contrary to the traditional concept, it is concluded that elevated androgen levels in patients with PCOS do not interfere with ovulation induction using pure FSH.
五名患有明确多囊卵巢综合征（PCOS）的患者接受了纯促卵泡激素（FSH）治疗以诱导排卵。每天测量血清雄烯二酮和睾酮水平，发现其显著升高，在排卵时达到最高值。然而，尽管雄激素水平升高，但每例患者均发生排卵，且三名患者受孕。与传统观念相反，得出的结论是，PCOS患者雄激素水平升高并不干扰使用纯FSH诱导排卵。
