Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences I, Lebanese University, Beirut, Lebanon.
J Cell Physiol. 2020 Feb;235(2):1568-1575. doi: 10.1002/jcp.29075. Epub 2019 Jul 16.
Despite increased social awareness, marketing restraints, tobacco taxation, and available smoking cessation rehab programs, active and passive smoking remain a worldwide challenging epidemic and a key risk factor for cardiovascular diseases development. Although cardiovascular (CV) protection is more pronounced in women than in men due to estrogenic effects, tobacco cigarette smoking exposure seems to alter this protection by modulating estrogen actions via undefined mechanisms. Premenopausal cigarette smoking women are at higher risk of adverse CV effects than non-smokers. In this study, we investigated the impact of cigarette smoking on early CV injury after myocardial infarction (MI) in non-menopausal female mice. Aortic arch calcification, fibrosis, reactive oxygen species, and gene expression of inflammatory and calcification genes were exaggerated in mice exposed to cigarette smoke (CS). These findings suggest that aortic injury following MI, characterized by vascular smooth muscle cells transdifferentiation, calcification, inflammation, and collagen deposition but not cardiac dysfunction is exacerbated with CS exposure. The novel findings of this study highlight the importance of aortic injury on short and long-term prognosis in CS-exposed MI females. Linking those findings to estrogen alteration is probable and entails investigation.
尽管社会意识增强、市场营销限制、烟草税收和现有的戒烟康复计划，但主动和被动吸烟仍然是全球范围内具有挑战性的流行疾病，也是心血管疾病发展的关键风险因素。尽管由于雌激素的作用，心血管（CV）保护在女性中比男性更为明显，但吸烟暴露似乎通过通过未定义的机制调节雌激素作用来改变这种保护。绝经前吸烟的女性比不吸烟者更容易出现不良 CV 影响。在这项研究中，我们研究了吸烟对非绝经雌性小鼠心肌梗死后早期心血管损伤的影响。与不吸烟的小鼠相比，暴露于香烟烟雾（CS）的小鼠的主动脉弓钙化、纤维化、活性氧和炎症及钙化基因的表达明显加重。这些发现表明，MI 后主动脉损伤，其特征为血管平滑肌细胞转分化、钙化、炎症和胶原沉积，但不伴有心功能障碍，随着 CS 暴露而加重。这项研究的新发现强调了 CS 暴露的 MI 女性的短期和长期预后中主动脉损伤的重要性。将这些发现与雌激素变化联系起来是可能的，需要进一步研究。
