Maurer K, Ihl R, Dierks T
Abteilung für Klinische, Neurophysiologie der Psychiatrischen Universitätsklinik, Würzburg.
EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1988 Mar;19(1):26-9.
The P300 wave undergoes alterations during physiological aging showing lower amplitudes and longer latencies in geriatric controls. By means of topographical display of P300-data it could be shown that the topography with maximal positivity at parietal sites is maintained in aging. In patients, however, suffering from senile dementia of Alzheimer's type signs of a frontal elevation and a parietal decrement of P300 amplitudes could be observed. The findings can be interpreted firstly as an indication that the frontal lobe is less effected. On the other side if a hippocampal dipole is assumed a neuronal lesion could lead to a turn of this dipole with the result of a now frontally located positivity.
P300波在生理衰老过程中会发生变化，在老年对照组中表现出较低的波幅和较长的潜伏期。通过P300数据的地形图显示可以看出，顶叶部位出现最大正电位的地形图在衰老过程中保持不变。然而，在患有阿尔茨海默型老年痴呆症的患者中，可以观察到P300波幅出现额叶抬高和顶叶降低的迹象。这些发现首先可以解释为额叶受影响较小的一个迹象。另一方面，如果假设存在海马偶极子，神经元损伤可能导致该偶极子发生转动，结果是现在正电位位于额叶。
