Neugebauer Dorota, Mielańczyk Anna, Bielas Rafał, Odrobińska Justyna, Kupczak Maria, Niesyto Katarzyna
Faculty of Chemistry, Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 44-100 Gliwice, Poland.
Pharmaceutics. 2019 Jul 15;11(7):337. doi: 10.3390/pharmaceutics11070337.
The presented drug delivery polymeric systems (DDS), i.e., conjugates and self-assemblies, based on grafted and star-shaped polymethacrylates have been studied for the last few years in our group. This minireview is focused on the relationship of polymer structure to drug conjugation/entrapment efficiency and release capability. Both graft and linear polymers containing trimethylammonium groups showed the ability to release the pharmaceutical anions by ionic exchange, but in aqueous solution they were also self-assembled into nanoparticles with encapsulated nonionic drugs. Star-shaped polymers functionalized with ionizable amine/carboxylic groups were investigated for drug conjugation via ketimine/amide linkers. However, only the conjugates of polybases were water-soluble, giving opportunity for release studies, whereas the self-assembling polyacidic stars were encapsulated with the model drugs. Depending on the type of drug loading in the polymer matrix, their release rates were ordered as follows: Physical ≥ ionic > covalent. The studies indicated that the well-defined ionic polymethacrylates, including poly(ionic liquid)s, are advantageous for designing macromolecular carriers due to the variety of structural parameters, which are efficient for tuning of drug loading and release behavior in respect to the specific drug interactions.
在过去几年里，我们团队对基于接枝和星形聚甲基丙烯酸酯的药物递送聚合物系统（DDS），即缀合物和自组装体进行了研究。本综述聚焦于聚合物结构与药物缀合/包封效率及释放能力之间的关系。含三甲铵基团的接枝聚合物和线性聚合物均显示出通过离子交换释放药物阴离子的能力，但在水溶液中它们也会自组装成包封非离子药物的纳米颗粒。对用可电离胺/羧基官能化的星形聚合物进行了通过酮亚胺/酰胺连接体进行药物缀合的研究。然而，只有多元碱的缀合物是水溶性的，从而有机会进行释放研究，而自组装的多元酸性星形聚合物则被模型药物包封。根据聚合物基质中药物负载类型的不同，它们的释放速率排序如下：物理包封≥离子交换＞共价结合。研究表明，包括聚（离子液体）在内的结构明确的离子型聚甲基丙烯酸酯，因其具有多种结构参数，在针对特定药物相互作用调节药物负载和释放行为方面很有效，所以有利于设计大分子载体。
