Association between Serum Uric Acid Level with Presence and Severity of Coronary Artery Disease.

AIM AND OBJECTIVES

This study has been undertaken to determine and compare the levels of serum uric acid in cases with and without coronary artery disease (CAD), to study association between serum uric acid (SUA) level with presence and severity of coronary artery disease.

METHODS

Total 80 cases more than 13 years of age who presented to hospital with symptoms related to CAD were included in the study and divided into two groups based on coronary angiography reports. Serum uric acid level was measured in all patients by Uricase method. Presence and severity of CAD was assessed by coronary angiography. Association of SUA level with presence and severity of CAD were assessed by statistical analysis.

RESULTS

In total, 39 (48.75%) of the patients were diagnosed with CAD having mean age of 56.71 ± 10.36 years. The CAD patients had significantly higher SUA levels than those without CAD, (7.35 ± 1.61mg/dl vs. 4.08 ± 0.83 mg/dl, p=<0.001).There was statistically significant association between SUA and severity of CAD. Serum uric acid levels were increased in cases with CAD with increase in severity of CAD (p < 0.001).

CONCLUSION

Serum uric acid was significantly associated with the presence and severity of CAD and can be used for assessing severity of CAD.