Influence oe calcium disodium edetate on the toxic effects of lead administration in pregnant rats. - Suppr | 超能文献

Influence oe calcium disodium edetate on the toxic effects of lead administration in pregnant rats.

作者信息

Flora S J, Tandon S K

机构信息

Industrial Toxicology Research Centre, Lucknow.

出版信息

Indian J Physiol Pharmacol. 1987 Oct-Dec;31(4):267-72.

Abstract

Adverse effects of lead on mothers and foetal development along with lead distribution and their alteration by calcium disodium ethylenediamine tetraacetate (CaNa2EDTA) were investigated in pregnant rats. The number of fetal resorption and abnormal fetuses increased and the number of live fetuses per dam and fetal weight decreased along with increase in liver, kidney, blood, brain and fetus lead levels by lead administration. The treatment with CaNa2EDTA significantly reduced these effects of lead. However, the chelating agent enhanced the placental level of lead. Neither lead nor CaNa2EDTA altered the zinc levels of maternal organs, placenta or fetus. The results suggest that many adverse effects of lead in pregnant rats can be favourably reduced by CaNa2EDTA.

摘要

相似文献

1

Influence oe calcium disodium edetate on the toxic effects of lead administration in pregnant rats.

Indian J Physiol Pharmacol. 1987 Oct-Dec;31(4):267-72.

2

The embryotoxicity of gossypol.

Teratology. 1985 Oct;32(2):251-7. doi: 10.1002/tera.1420320213.

3

Fetal, neonatal, and long-term alterations in hepatic retinoid levels following maternal polychlorinated biphenyl exposure in rats.大鼠母体暴露于多氯联苯后肝脏类视黄醇水平的胎儿期、新生儿期及长期改变。

Toxicol Appl Pharmacol. 1995 Mar;131(1):175-82. doi: 10.1006/taap.1995.1059.

4

The effects of lead exposure on placental NF-kappaB expression and the consequences for gestation.铅暴露对胎盘核因子-κB表达的影响及其对妊娠的后果。

Reprod Toxicol. 2009 Apr;27(2):190-5. doi: 10.1016/j.reprotox.2008.12.006. Epub 2008 Dec 30.

5

Protective effect of Tiron (4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt) against beryllium-induced maternal and fetal toxicity in rats.钛铁试剂（4,5-二羟基苯-1,3-二磺酸钠盐）对铍诱导的大鼠母体和胎儿毒性的保护作用。

Arch Toxicol. 2002 Aug;76(8):442-8. doi: 10.1007/s00204-002-0356-4. Epub 2002 Jun 27.

6

Distribution and effects of intravenous lead in the fetoplacental unit of the rat.

J Toxicol Environ Health. 1982 May-Jun;9(5-6):1021-32. doi: 10.1080/15287398209530222.

7

Valproic acid-induced placental and teratogenic effects in rats.

Teratology. 1992 Jun;45(6):603-10. doi: 10.1002/tera.1420450605.

8

[Studies on effects of sodium benzoate on fetuses and offspring of Wistar rats (author's transl)].

Eisei Shikenjo Hokoku. 1978(96):47-55.

9

Effects of tert-butyl acetate on maternal toxicity and embryo-fetal development in Sprague-Dawley rats.乙酸叔丁酯对Sprague-Dawley大鼠母体毒性及胚胎-胎儿发育的影响。

Birth Defects Res B Dev Reprod Toxicol. 2007 Oct;80(5):374-82. doi: 10.1002/bdrb.20124.

10

Developmental toxicity evaluation of emodin in rats and mice.大黄素对大鼠和小鼠的发育毒性评价

Birth Defects Res B Dev Reprod Toxicol. 2004 Apr;71(2):89-101. doi: 10.1002/bdrb.20002.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。