Kilitci Asuman, Arıoz Okan
Department of Pathology, Ahi Evran University School of Medicine, Kırşehir, Turkey.
Department of Gynecology and Obstetrics, Ahi Evran University Training and Research Hospital, Kırşehir, Turkey.
Eur J Breast Health. 2019 Jul 1;15(3):196-199. doi: 10.5152/ejbh.2019.4391. eCollection 2019 Jul.
Phyllodes tumor (PT) of the vulva is very rarely seen and has been reported in only 17 cases in English literature. It is still uncertain that proliferative mammary gland lesions including PT in the anogenital region originate from ectopic breast tissue or from local adnexal structures. We report a case of primary benign PT of the vulva in a 41-year-old female patient. Microscopic examination revealed biphasic tumoral formation with typically extensive leaf-like papillary structures growing toward slit-like spaces under the skin. In immunohistochemical examination, more than 50% of epithelial cells showed a positive reaction with ER, PR, and panCK and a focal positive reaction with GCDFP-15. Myoepithelial cells showed a positive reaction with SMA, CD10, and WT-1. In this report, we underline the clinicopathologic features of PT localized to an unusual site, and also discuss its etiology, differential diagnosis in the light of the current literature.
外阴叶状肿瘤（PT）极为罕见，英文文献中仅报道过17例。包括PT在内的生殖区域增生性乳腺病变究竟起源于异位乳腺组织还是局部附属结构，目前仍不明确。我们报告一例41岁女性患者的原发性外阴良性PT。显微镜检查显示为双相肿瘤形成，典型表现为广泛的叶状乳头状结构向皮下裂隙样间隙生长。免疫组化检查中，超过50%的上皮细胞对雌激素受体（ER）、孕激素受体（PR）和广谱细胞角蛋白（panCK）呈阳性反应，对GCDFP - 15呈局灶性阳性反应。肌上皮细胞对平滑肌肌动蛋白（SMA）、CD10和威尔姆斯瘤蛋白1（WT - 1）呈阳性反应。在本报告中，我们强调了发生于不寻常部位的PT的临床病理特征，并结合当前文献讨论了其病因及鉴别诊断。
