Pouzot-Nevoret C, Hocine L, Nègre J, Goy-Thollot I, Barthélemy A, Boselli E, Bonnet J M, Allaouchiche B
Intensive Care Unit (SIAMU), Université de Lyon, VetAgro Sup, APCSe, Marcy l'Etoile, F-69280, France.
Université de Lyon, VetAgro Sup, APCSe, Marcy l'Etoile, F-69280, France.
J Small Anim Pract. 2019 Nov;60(11):656-662. doi: 10.1111/jsap.13058. Epub 2019 Jul 16.
To describe the use, effectiveness and tolerance of high-flow oxygen therapy in dyspnoeic dogs.
Prospectively, dogs in acute respiratory distress admitted to an intensive care unit between January and May 2018 that failed to respond to nasal oxygen therapy and medical stabilisation after 30 minutes were transitioned to high-flow oxygen therapy. High-flow oxygen therapy, delivered an inspired oxygen fraction of 100% using an air/oxygen blender, active humidifier, single warmed tube and specific nasal cannula. Respiratory rate, pulse oximetry (SpO ), heart rate and a tolerance score were assessed every 15 minutes from T (under nasal oxygen) to 1 hour (T ), and PaO and PaCO at T and T . Complications were recorded for each dog.
Eleven dogs were included. At T , PaO , flow rate and SpO were significantly greater than at T (171 ± 123 versus 73 ± 24 mmHg; P=0.015; 18 ±12 L/minute versus 3.2 ± 2.0 L/minute, P<0.01; 97.7 ±2.3% versus 91.6 ±7.2%, P=0.03, respectively). There was no significant difference in PaCO , respiratory rate or heart rate between T and T . Tolerance was excellent, and there were no complications.
High-flow oxygen therapy improves markers of oxygenation in dyspnoeic dogs and is an effective means to deliver oxygen with comfort and minimal complications.
描述高流量氧疗在呼吸困难犬中的应用、有效性和耐受性。
前瞻性研究，2018年1月至5月入住重症监护病房的急性呼吸窘迫犬，在接受鼻导管吸氧治疗30分钟后对药物稳定治疗无反应，转而接受高流量氧疗。高流量氧疗使用空气/氧气混合器、主动加湿器、单根加温管和特定的鼻导管输送100%的吸入氧分数。从T0（鼻导管吸氧时）到T1（1小时），每隔15分钟评估呼吸频率、脉搏血氧饱和度（SpO₂）、心率和耐受性评分，并在T0和T1时评估动脉血氧分压（PaO₂）和动脉血二氧化碳分压（PaCO₂）。记录每只犬的并发症情况。
纳入11只犬。在T1时，PaO₂、流速和SpO₂显著高于T0（分别为171±123 vs 73±24 mmHg；P = 0.015；18±12 L/分钟 vs 3.2±2.0 L/分钟，P < 0.01；97.7±2.3% vs 91.6±7.2%，P = 0.03）。T0和T1之间PaCO₂、呼吸频率或心率无显著差异。耐受性良好，无并发症发生。
高流量氧疗可改善呼吸困难犬的氧合指标，是一种舒适且并发症最少的有效给氧方式。
