眼型活动性和眼型非活动性贝赫切特病患者的血清皮质抑素水平。

Serum Cortistatin Levels in Patients with Ocular Active and Ocular Inactive Behçet Disease.

机构信息

Faculty of Medicine, Department of Ophthalmology, Fırat University , Elazığ, Turkey.

Faculty of Medicine, Department of Ophthalmology, Abant Izzet Baysal University , Bolu, Turkey.

出版信息

Ocul Immunol Inflamm. 2020 May 18;28(4):601-605. doi: 10.1080/09273948.2019.1610461. Epub 2019 Jul 17.

DOI:10.1080/09273948.2019.1610461

PMID:31314641

Abstract

PURPOSE

To evaluate serum cortistatin (CST) levels in patients with ocular active and ocular inactive Behçet disease (BD) and its relationship with disease activity.

METHODS

24 BD patients with ocular active, 24 BD patients with ocular inactive patients and 24 healthy control subjects were included in the study.

RESULTS

In ocular active and ocular inactive BD patients and healthy control subjects, the mean serum CST levels were 4.38 ± 1.63ng/ml, 5.46 ± 1.81ng/ml and 7.56 ± 1.73ng/ml, respectively. ESR, serum CRP, CST levels and NLR were significantly different between the groups (p < 0.001 for all). The CST levels were similar between ocular active and inactive BD patient groups (p = 0.197). ESR, CRP and NLR were significantly higher in ocular active BD patients compared to ocular inactive BD patients and healthy control subjects (p < 0.05 for all).

CONCLUSION

Serum CST level was significantly lower in BD patients. CST may be a neuropeptide that plays a role in the pathogenesis of BD.

摘要

目的

评估眼部活动性和眼部非活动性贝赫切特病（BD）患者的血清皮质抑素（CST）水平及其与疾病活动度的关系。

方法

本研究纳入了 24 例眼部活动性 BD 患者、24 例眼部非活动性 BD 患者和 24 名健康对照者。

结果

在眼部活动性和眼部非活动性 BD 患者以及健康对照组中，血清 CST 水平的平均值分别为 4.38±1.63ng/ml、5.46±1.81ng/ml 和 7.56±1.73ng/ml。ESR、血清 CRP、CST 水平和 NLR 在各组间差异均有统计学意义（p＜0.001）。眼部活动性和非活动性 BD 患者组间 CST 水平无显著差异（p=0.197）。与眼部非活动性 BD 患者和健康对照组相比，眼部活动性 BD 患者的 ESR、CRP 和 NLR 均显著升高（p＜0.05）。