Department of Oral and Maxillofacial Surgery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Interferon Cytokine Res. 2019 Dec;39(12):727-739. doi: 10.1089/jir.2019.0070. Epub 2019 Jul 17.
This meta-analysis aimed to assess the salivary and serum concentrations of IL-6 and IL-8 in oral squamous cell carcinoma (OSCC) patients compared to the controls. Four electronic databases (Scopus, PubMed, Cochrane Library, and Web of Science) were searched up to January 2019. The study quality was checked according to the Newcastle-Ottawa Scale. The mean difference (MD) plus 95% confidence interval (95%CI) were calculated using RevMan 5.3 software. The publication bias and sensitivity analysis were done using CMA 2.0 software. Out of 309 studies retrieved from the 4 databases, 26 studies were analyzed in the present meta-analysis. In this meta-analysis, the pooled MD in the OSCC patients compared to the controls was 19.06 pg/mL (95%CI: 14.78-23.33) for the serum IL-6 level, 199.14 pg/mL (95%CI: 47.39-350.89) for the serum IL-8 level, 122 pg/mL (95%CI: 64-179) for the salivary IL-6 level, and 958 pg/dL (95%CI: 718-1197) for the salivary IL-8 level. All values in this meta-analysis were statistically significant. In conclusion, according to the meta-analysis results, the serum and salivary IL-6 and IL-8 levels in OSCC patients were significantly elevated compared to the controls, and both cytokines can be useful as potential biomarkers in early OSCC diagnosis.
本荟萃分析旨在评估口腔鳞状细胞癌（OSCC）患者与对照组相比的唾液和血清中 IL-6 和 IL-8 的浓度。我们检索了四个电子数据库（Scopus、PubMed、Cochrane Library 和 Web of Science），检索时间截至 2019 年 1 月。根据 Newcastle-Ottawa 量表检查研究质量。使用 RevMan 5.3 软件计算平均值差（MD）加 95%置信区间（95%CI）。使用 CMA 2.0 软件进行发表偏倚和敏感性分析。从这 4 个数据库中检索到 309 项研究，其中 26 项研究纳入本荟萃分析。在本荟萃分析中，与对照组相比，OSCC 患者的血清 IL-6 水平的合并 MD 为 19.06pg/mL（95%CI：14.78-23.33），血清 IL-8 水平为 199.14pg/mL（95%CI：47.39-350.89），唾液 IL-6 水平为 122pg/mL（95%CI：64-179），唾液 IL-8 水平为 958pg/dL（95%CI：718-1197）。本荟萃分析中的所有值均具有统计学意义。总之，根据荟萃分析结果，与对照组相比，OSCC 患者的血清和唾液 IL-6 和 IL-8 水平显著升高，这两种细胞因子均可作为早期 OSCC 诊断的潜在生物标志物。
