Department of Epidemiology, School of Public Health, Fudan University, NO 130, Dongan Road, Xuhui District, Shanghai 200032, China.
Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China.
Nutrients. 2019 Jul 16;11(7):1614. doi: 10.3390/nu11071614.
Obesity and homocysteine (Hcy) are two important risk factors for cardiovascular disease (CVD). However, evidence on the association between obesity and Hcy concentration was conflicting. The aim of our study is to explore the associations of general and central obesity with hyperhomocysteinemia (HHcy) in middle-aged women.
The current analysis was based on data from 11,007 women aged 40-60 years. Height, weight, and waist circumference (WC) were measured and serum homocysteine was determined. Multiple logistic regression models were used to assess the associations of the risk of hyperhomocysteinemia (HHcy, Hcy > 15 μmol/L) with BMI and WC.
13.71% women had HHcy. The prevalences of BMI-based general obesity and WC-based central obesity were 11.17% and 22.88%, respectively. Compared with non-obese women, the mean serum Hcy concentration was significantly higher in WC-based central obese women ( = 0.002), but not in BMI-based general obese women ( > 0.05). In the multiple logistic regression models, central obesity was positively related to the risk of HHcy (OR = 1.30, 95% CI = 1.10 to 1.52), while general obesity was inversely related to the risk of HHcy (OR = 0.82, 95% CI = 0.72 to 0.93 and OR = 0.71, 95% CI = 0.57 to 0.89).
Central obesity was positively related to the risk of HHcy, while general obesity was negatively related. Menopause showed no effect modification on these associations.
肥胖和同型半胱氨酸（Hcy）是心血管疾病（CVD）的两个重要危险因素。然而，肥胖与 Hcy 浓度之间的关系的证据存在矛盾。我们的研究目的是探讨中年女性中一般性肥胖和中心性肥胖与高同型半胱氨酸血症（HHcy）的关系。
本分析基于来自 11007 名年龄在 40-60 岁的女性的数据。测量身高、体重和腰围（WC），并测定血清同型半胱氨酸。使用多因素 logistic 回归模型评估 HHcy（Hcy > 15 μmol/L）风险与 BMI 和 WC 的关联。
13.71%的女性患有 HHcy。BMI 定义的一般性肥胖和 WC 定义的中心性肥胖的患病率分别为 11.17%和 22.88%。与非肥胖女性相比，WC 定义的中心性肥胖女性的血清 Hcy 浓度明显更高（ = 0.002），但 BMI 定义的一般性肥胖女性则不然（ > 0.05）。在多因素 logistic 回归模型中，中心性肥胖与 HHcy 的风险呈正相关（OR = 1.30，95%CI = 1.10-1.52），而一般性肥胖与 HHcy 的风险呈负相关（OR = 0.82，95%CI = 0.72-0.93 和 OR = 0.71，95%CI = 0.57-0.89）。
中心性肥胖与 HHcy 的风险呈正相关，而一般性肥胖与 HHcy 的风险呈负相关。绝经对这些关联没有影响修饰作用。
