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类核酸结构。III. 3'-脱氧腺苷2',5'-二磷酸咪唑化物的寡聚化

Nucleic acid-like structures. III. Oligomerization of 3'-deoxyadenosine 2',5'-diphosphoimidazolide.

作者信息

Visscher J, Schwartz A W

机构信息

Laboratory for Exobiology, Faculty of Science, University of Nijmegen, The Netherlands.

出版信息

J Mol Evol. 1987;26(4):291-3. doi: 10.1007/BF02101146.

DOI:10.1007/BF02101146
PMID:3131530
Abstract

The activated dimonophosphate of 3'-deoxyadenosine (cordycepin) undergoes oligomerization to produce a new family of pyrophosphate-linked oligomers in which the average repeating unit involves a nine-atom structural group. The presence of a poly(U) template increases the relative yields of higher oligomers, although the template-free reaction is itself extremely efficient.

摘要

3'-脱氧腺苷(虫草素)的活化二磷酸发生寡聚化,生成一类新的焦磷酸连接的寡聚物,其中平均重复单元包含一个九原子结构基团。聚(U)模板的存在提高了高级寡聚物的相对产率,尽管无模板反应本身效率极高。

相似文献

1
Nucleic acid-like structures. III. Oligomerization of 3'-deoxyadenosine 2',5'-diphosphoimidazolide.类核酸结构。III. 3'-脱氧腺苷2',5'-二磷酸咪唑化物的寡聚化
J Mol Evol. 1987;26(4):291-3. doi: 10.1007/BF02101146.
2
Oligomerizations of deoxyadenosine bis-phosphates and of their 3'-5', 3'-3', and 5'-5' dimers: effects of a pyrophosphate-linked, poly(T) analog.脱氧腺苷二磷酸及其3'-5'、3'-3'和5'-5'二聚体的寡聚化:焦磷酸连接的聚(T)类似物的作用。
Orig Life Evol Biosph. 1990;20(5):369-75. doi: 10.1007/BF01808131.
3
Template-directed synthesis of novel, nucleic acid-like structures.新型核酸样结构的模板导向合成。
Science. 1985 May 3;228:585-7. doi: 10.1126/science.228.4699.585.
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Disulfide-linked oligonucleotide phosphorothioates: novel analogues of nucleic acids.二硫键连接的寡核苷酸硫代磷酸酯:新型核酸类似物
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Synthesis of 1-N-oxides of deoxyadenosine and deoxyadenosine monophosphate.脱氧腺苷和脱氧腺苷一磷酸1-N-氧化物的合成。
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Cordycepin analogues of 2-5A and its derivatives. Chemical synthesis and biological activity.2-5A及其衍生物的虫草素类似物。化学合成与生物活性。
J Biol Chem. 1983 Feb 10;258(3):1671-7.
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Template-directed oligomerization catalyzed by a polynucleotide analog.
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Formation in vitro of deoxyadenosine triphosphate from deoxyadenosine in Ehrlich ascites cells.艾氏腹水癌细胞中由脱氧腺苷体外形成三磷酸脱氧腺苷
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[A simple enzymatic method for the quantitative determination of cordycepin and [3'-deoxy]ATP in rat brain tissue].[一种用于定量测定大鼠脑组织中虫草素和[3'-脱氧]ATP的简单酶法]
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引用本文的文献

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Template-directed oligomerization of 5'-deoxy-5'-nucleosideacetic acid derivatives.5'-脱氧-5'-核苷乙酸衍生物的模板导向寡聚化
Orig Life Evol Biosph. 1990;20:151-60. doi: 10.1007/BF01808276.
2
Template-directed synthesis of acyclic oligonucleotide analogues.
J Mol Evol. 1988;28(1-2):3-6. doi: 10.1007/BF02143492.
3
Template-directed oligomerization of 3-isoadenosine 5'-phosphate.
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本文引用的文献

1
Template-directed synthesis of novel, nucleic acid-like structures.新型核酸样结构的模板导向合成。
Science. 1985 May 3;228:585-7. doi: 10.1126/science.228.4699.585.
2
A nonenzymatic RNA polymerase model.一种非酶促RNA聚合酶模型。
Science. 1983 Feb 18;219(4586):859-62. doi: 10.1126/science.6186026.
3
Seven-membered cyclic phosphate: synthesis and properties of S-cycloadenosine 2',5'-cyclic phosphate and cordycepin 2',5'-cyclic phosphate. Studies of nucleosides and nucleotides. LXIV. 1). Purine cyclonucleosides 25.
Manganese-catalyzed oligomerizations of nucleotide analogs.
J Mol Evol. 1989 Oct;29(4):284-7. doi: 10.1007/BF02103615.
七元环磷酸酯:S-环腺苷2',5'-环磷酸酯和虫草素2',5'-环磷酸酯的合成与性质。核苷与核苷酸研究。LXIV。1). 嘌呤环核苷25。
Nucleic Acids Res. 1974 Dec;1(12):1783-98. doi: 10.1093/nar/1.12.1783.
4
Nucleic acid-like structures. II. Polynucleotide analogues as possible primitive precursors of nucleic acids.
Orig Life Evol Biosph. 1987;17(3-4):351-7. doi: 10.1007/BF02386473.
5
The case for an ancestral genetic system involving simple analogues of the nucleotides.关于一个涉及核苷酸简单类似物的祖传遗传系统的情况。
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4398-402. doi: 10.1073/pnas.84.13.4398.