García-Tejedor A, Castaño A R, Morán F, Montero F
Departamento de Bioquímica, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.
J Mol Evol. 1987;26(4):294-300. doi: 10.1007/BF02101147.
The most relevant properties of hypercycles were previously studied mainly from a theoretical point of view. We have developed a Monte Carlo method simulating hypercyclic organization to obtain information about the dynamics of this prebiotic organization. Nucleation, growth, and selective properties have been tested and the results obtained are in good agreement with those of the theoretical predictions. The influence of hypercyclic organization on the "error threshold" has also been studied. As a consequence of the emergence of a hypercycle, the value of this threshold decreases. The amount of this decrease depends on the population size. Moreover, for some interval of quality factor values, either the hypercycle organization or an error catastrophe can be produced, depending on the initial conditions. The influence of these phenomena on both the dynamic behavior and evolutionary advantages of the hypercycle, as well as their decisive roles on genome size, are discussed.
超循环最相关的特性之前主要是从理论角度进行研究的。我们开发了一种模拟超循环组织的蒙特卡罗方法，以获取有关这种前生物组织动力学的信息。对成核、生长和选择性特性进行了测试，所得结果与理论预测结果高度吻合。还研究了超循环组织对“错误阈值”的影响。超循环出现的结果是，这个阈值的值降低。降低的幅度取决于种群规模。此外，对于质量因子值的某些区间，根据初始条件，要么会产生超循环组织，要么会发生误差灾难。讨论了这些现象对超循环的动态行为和进化优势的影响，以及它们对基因组大小的决定性作用。
