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[PD-1/PD-L1检查点抑制剂治疗非小细胞肺癌的临床研究进展]

[Progress in Clinical Researches of PD-1/PD-L1 Checkpoint Inhibitor for Non-small Cell Lung Cancer].

作者信息

Wu Sixuan, Hu Chunhong, Wu Fang, Wu Yuanqiang, Liu Ping

机构信息

Department of Oncology, the Second Xiangya Hospital, Central South University, Changsha 410011, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2019 Jul 20;22(7):440-448. doi: 10.3779/j.issn.1009-3419.2019.07.06.

Abstract

Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors, especially programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have made a breakthrough in the treatment of NSCLC and changed the treatment pattern for NSCLC. Immunological checkpoint inhibitors targeting PD-1/PD-L1 are beneficial to patients, both in the first-line and second-line treatment of advanced NSCLC, in the adjuvant treatment of locally-advanced NSCLC, and in the neoadjuvant therapy of early NSCLC, which show an important role in the comprehensive treatment of NSCLC. This article reviews the clinical research progress of immunological checkpoint inhibitors targeting PD-1/PD-L1 in NSCLC.
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摘要

非小细胞肺癌(NSCLC)是肺癌最常见的病理类型。近年来,免疫疗法发展迅速。免疫检查点抑制剂,尤其是程序性死亡受体1(PD-1)/程序性死亡配体1(PD-L1)抑制剂在NSCLC治疗方面取得了突破,改变了NSCLC的治疗模式。靶向PD-1/PD-L1的免疫检查点抑制剂对患者有益,无论是在晚期NSCLC的一线和二线治疗中,还是在局部晚期NSCLC的辅助治疗以及早期NSCLC的新辅助治疗中,都在NSCLC的综合治疗中发挥着重要作用。本文综述了靶向PD-1/PD-L1的免疫检查点抑制剂在NSCLC中的临床研究进展。

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本文引用的文献

1
Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer.帕博利珠单抗联合化疗用于鳞状非小细胞肺癌。
N Engl J Med. 2018 Nov 22;379(21):2040-2051. doi: 10.1056/NEJMoa1810865. Epub 2018 Sep 25.
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Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.新辅助 PD-1 阻断治疗可切除性肺癌。
N Engl J Med. 2018 May 24;378(21):1976-1986. doi: 10.1056/NEJMoa1716078. Epub 2018 Apr 16.

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