Layman Awo Akosua K, Joshi Shivam, Shah Sanjeev
Perelman School of Medicine, Medical Scientist Training Program, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Internal Medicine, New York University, New York, New York, USA.
BMJ Case Rep. 2019 Jul 16;12(7):e229434. doi: 10.1136/bcr-2019-229434.
Tumour-induced osteomalacia (TIO), or oncogenic osteomalacia, is a paraneoplastic syndrome marked by hypophosphataemia, renal phosphate wasting, bone pain, weakness, and fractures. The syndrome has been reported with both benign and malignant tumours including parotid gland basal cell tumours, thyroid carcinomas, colon adenocarcinomas, and prostate cancer. Often, the syndrome is marked by an insidious course during which patients present with generalised bony pain and weakness, which do not resolve until the underlying tumour is identified and treated. We present a case of a patient with Parkinson's disease whose subacute weakness, lower extremity paresis, and renal phosphate wasting led to the synchronous diagnosis of metastatic prostate adenocarcinoma and TIO.
肿瘤诱导的骨软化症（TIO），即致癌性骨软化症，是一种副肿瘤综合征，其特征为低磷血症、肾磷酸盐 wasting、骨痛、虚弱和骨折。该综合征已在良性和恶性肿瘤中均有报道，包括腮腺基底细胞瘤、甲状腺癌、结肠腺癌和前列腺癌。通常，该综合征病程隐匿，患者表现为全身性骨痛和虚弱，直到发现并治疗潜在肿瘤才会缓解。我们报告一例帕金森病患者，其亚急性虚弱、下肢轻瘫和肾磷酸盐 wasting 导致转移性前列腺腺癌和 TIO 的同步诊断。
