INSERM, SSA, IRBA, MCT, Aix Marseille University, Marseille, France
Department of Microbiology, U1047, INSERM, University Montpellier and University Hospital Nîmes, Nîmes, France.
Clin Microbiol Rev. 2019 Jul 17;32(4). doi: 10.1128/CMR.00002-19. Print 2019 Sep 18.
The genus is a member of the ESKAPE group, which contains the major resistant bacterial pathogens. First described in 1960, this group member has proven to be more complex as a result of the exponential evolution of phenotypic and genotypic methods. Today, 22 species belong to the genus. These species are described in the environment and have been reported as opportunistic pathogens in plants, animals, and humans. The pathogenicity/virulence of this bacterium remains rather unclear due to the limited amount of work performed to date in this field. In contrast, its resistance against antibacterial agents has been extensively studied. In the face of antibiotic treatment, it is able to manage different mechanisms of resistance via various local and global regulator genes and the modulation of the expression of different proteins, including enzymes (β-lactamases, etc.) or membrane transporters, such as porins and efflux pumps. During various hospital outbreaks, the and complex exhibited a multidrug-resistant phenotype, which has stimulated questions about the role of cascade regulation in the emergence of these well-adapted clones.
该属是 ESKAPE 集团的成员之一，该集团包含主要的耐药细菌病原体。该属成员于 1960 年首次被描述，由于表型和基因型方法的指数级进化，其结果证明更加复杂。如今，有 22 个种属于 属。这些物种在环境中被描述，并被报道为植物、动物和人类中的机会性病原体。由于迄今为止在该领域开展的工作有限，该细菌的致病性/毒力仍不太清楚。相比之下，其对抗菌药物的耐药性已得到广泛研究。在抗生素治疗的情况下，它能够通过各种局部和全局调节剂基因以及不同蛋白质（包括酶[β-内酰胺酶等]或膜转运蛋白，如孔蛋白和外排泵）表达的调节来管理不同的耐药机制。在各种医院暴发中， 和 复合体表现出多药耐药表型，这引发了关于级联调节在这些适应性良好的克隆出现中的作用的问题。
