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染色质重塑机器在癌症中的多样组成和功能。

Diverse compositions and functions of chromatin remodeling machines in cancer.

机构信息

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Email:

出版信息

Sci Transl Med. 2019 Jul 17;11(501). doi: 10.1126/scitranslmed.aay1018.

DOI:10.1126/scitranslmed.aay1018
PMID:31316005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6755912/
Abstract

Human cancer genetics power biochemical and functional interrogation of chromatin remodeling complexes, informing therapeutic opportunities.

摘要

人类癌症遗传学为染色质重塑复合物的生化和功能研究提供了动力，为治疗提供了新的机会。

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Diverse compositions and functions of chromatin remodeling machines in cancer.染色质重塑机器在癌症中的多样组成和功能。
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Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease.哺乳动物SWI/SNF染色质重塑复合物在人类疾病中的组成与功能
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本文引用的文献

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The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting.哺乳动物 SWI/SNF 家族复合物的 ATP 酶模块介导亚基复合物身份和与催化活性无关的基因组靶向。
Nat Genet. 2019 Apr;51(4):618-626. doi: 10.1038/s41588-019-0363-5. Epub 2019 Mar 11.
2
A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation.非典型 SWI/SNF 复合物是由 BAF 复合物扰动驱动的癌症的合成致死靶点。
Nat Cell Biol. 2018 Dec;20(12):1410-1420. doi: 10.1038/s41556-018-0221-1. Epub 2018 Nov 5.
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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes.
泛癌症表观遗传因子表达景观预测肿瘤结局。
Commun Biol. 2023 Nov 16;6(1):1138. doi: 10.1038/s42003-023-05459-w.
4
Dual blockade of BRD4 and ATR/WEE1 pathways exploits loss in clear cell ovarian cancer.BRD4和ATR/WEE1通路的双重阻断可利用透明细胞卵巢癌中的缺陷。
Res Sq. 2023 Sep 27:rs.3.rs-3314138. doi: 10.21203/rs.3.rs-3314138/v1.
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In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis.体内筛选鉴定正常和恶性造血过程中染色质因子的功能。
Nat Genet. 2023 Sep;55(9):1542-1554. doi: 10.1038/s41588-023-01471-2. Epub 2023 Aug 14.
6
The Chromatin Remodeler HELLS: A New Regulator in DNA Repair, Genome Maintenance, and Cancer.染色质重塑酶 HELLS：DNA 修复、基因组维护和癌症的新调控因子。
Int J Mol Sci. 2022 Aug 18;23(16):9313. doi: 10.3390/ijms23169313.
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