小胎龄早产儿的肾功能。
Renal function in small for gestational age preterm infants.
机构信息
Department of Neonatology, Cleveland Clinic Children's hospital, Cleveland, OH, USA.
Department of Pediatrics, Cairo University, Cairo, Egypt.
出版信息
J Perinatol. 2019 Sep;39(9):1263-1267. doi: 10.1038/s41372-019-0431-9. Epub 2019 Jul 17.
OBJECTIVE
The objective of this study is to compare glomerular and tubular functions in small for gestational age (SGA) and appropriate for gestational age (AGA) preterm infants.
STUDY DESIGN
A prospective controlled study was conducted on SGA and AGA infants with gestational ages between 32 and 36 weeks, who received gentamycin in the first 72 h of life. Glomerular and tubular functions were assessed on days 1 and 5.
RESULTS
Fifty (25 SGA and 25 AGA) infants were included. On day of life 1, SGA group had higher serum sodium, serum urea, and urinary creatinine. On day 5, SGA infants had significant increase in serum creatinine (p = 0.04). Urinary NAG and FeNa were comparable among the two groups on days 1 and 5.
CONCLUSIONS
Glomerular functions were compromised in SGA preterm infants. Tubular functions were comparable.
目的
本研究旨在比较小于胎龄儿（SGA）和适于胎龄儿（AGA）早产儿的肾小球和肾小管功能。
研究设计
对胎龄在 32 至 36 周之间、出生后 72 小时内接受庆大霉素治疗的 SGA 和 AGA 早产儿进行前瞻性对照研究。在第 1 天和第 5 天评估肾小球和肾小管功能。
结果
共纳入 50 名（25 名 SGA 和 25 名 AGA）婴儿。在生后第 1 天，SGA 组的血清钠、血清尿素和尿肌酐较高。在第 5 天，SGA 婴儿的血清肌酐显著升高（p=0.04）。在第 1 天和第 5 天，两组的尿 NAG 和 FeNa 相似。
结论
SGA 早产儿的肾小球功能受损，而肾小管功能无差异。
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