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重型地中海贫血患者因心脏铁负荷导致的QT间期延长及相关室性心动过速

QT Prolongation and Associated Ventricular Tachycardia due to Cardiac Iron Load in a Patient with Thalassemia Major.

作者信息

Demirtas Derya, Demirtas Abdullah Orhan, Sumbul Hilmi Erdem, Koc Ayse Selcan

机构信息

Assistant Professor in Department of Internal Medicine, Adana Health Practice and Research Center, Health Sciences University, Adana, Turkey.

Assistant Professor in Department of Cardiology, Adana Health Practice and Research Center, Health Sciences University, Adana, Turkey.

出版信息

Case Rep Hematol. 2019 Jun 17;2019:5791094. doi: 10.1155/2019/5791094. eCollection 2019.

DOI:10.1155/2019/5791094
PMID:31316843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6604464/
Abstract

We report the case of a 23-year-old male with thalassemia major who developed long QT and continuous ventricular tachycardia (VT). Electrocardiography, echocardiography, and cardiac magnetic resonance imaging (MRI) were used for diagnosis and risk stratification. VT causes and treatments are presented and discussed. Ventricular arrhythmia can be treated by normalizing QT interval with high-dose beta-blocker therapy. However, MRI-compatible internal cardiac defibrillator implantation was performed due to the high risk in this patient.

摘要

我们报告了一例23岁重型地中海贫血男性患者，该患者出现了长QT间期和持续性室性心动过速（VT）。采用心电图、超声心动图和心脏磁共振成像（MRI）进行诊断和风险分层。介绍并讨论了室性心动过速的病因及治疗方法。室性心律失常可通过大剂量β受体阻滞剂治疗使QT间期正常化来进行治疗。然而，由于该患者风险较高，故进行了磁共振成像兼容型体内心脏除颤器植入术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6604464/a114640ba11a/CRIHEM2019-5791094.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6604464/70a561a741d2/CRIHEM2019-5791094.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6604464/a114640ba11a/CRIHEM2019-5791094.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6604464/70a561a741d2/CRIHEM2019-5791094.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6604464/a114640ba11a/CRIHEM2019-5791094.002.jpg

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本文引用的文献

1
2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.2017年美国心脏协会/美国心脏病学会/心律学会室性心律失常患者管理和心脏性猝死预防指南：执行摘要：美国心脏病学会/美国心脏协会临床实践指南工作组和心律学会报告
Heart Rhythm. 2018 Oct;15(10):e190-e252. doi: 10.1016/j.hrthm.2017.10.035. Epub 2017 Oct 30.
2
Ventricular tachycardia in iron man.钢铁侠中的室性心动过速。
HeartRhythm Case Rep. 2015 Nov 23;2(1):98-100. doi: 10.1016/j.hrcr.2015.11.009. eCollection 2016 Jan.
3
Sustained ventricular tachycardia in a patient with thalassemia major.
重型地中海贫血患者出现持续性室性心动过速。
Ann Noninvasive Electrocardiol. 2014 Mar;19(2):193-7. doi: 10.1111/anec.12085. Epub 2013 Sep 9.
4
The Association between Myocardial Iron Load and Ventricular Repolarization Parameters in Asymptomatic Beta-Thalassemia Patients.无症状β地中海贫血患者心肌铁负荷与心室复极参数之间的关联
Adv Hematol. 2012;2012:170510. doi: 10.1155/2012/170510. Epub 2012 May 15.
5
Long-term efficacy of deferasirox in preventing cardiovascular complications in the iron-overloaded gerbil.去铁酮在预防铁过载沙鼠心血管并发症中的长期疗效。
J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):117-25. doi: 10.1177/1074248411407635. Epub 2011 May 18.
6
On T2* magnetic resonance and cardiac iron.T2* 磁共振与心脏铁沉积
Circulation. 2011 Apr 12;123(14):1519-28. doi: 10.1161/CIRCULATIONAHA.110.007641. Epub 2011 Mar 28.
7
Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major.心脏T2*磁共振成像预测重型地中海贫血患者心脏并发症的研究
Circulation. 2009 Nov 17;120(20):1961-8. doi: 10.1161/CIRCULATIONAHA.109.874487. Epub 2009 Oct 2.
8
Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron-overload cardiomyopathy.去铁胺可促进铁过载性心肌病沙鼠模型的存活并预防心电图异常。
J Lab Clin Med. 2003 Feb;141(2):121-30. doi: 10.1067/mlc.2003.18.