血管活性肠肽拮抗剂对猫气道非肾上腺素能非胆碱能抑制反应的影响。

The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways.

作者信息

Thompson D C, Altiere R J, Diamond L

机构信息

Division of Pharmacology and Toxicology, College of Pharmacy, University of Kentucky, Lexington 40536.

出版信息

Peptides. 1988 Mar-Apr;9(2):443-7. doi: 10.1016/0196-9781(88)90284-7.

DOI:10.1016/0196-9781(88)90284-7

PMID:3131749

Abstract

Relaxations of the feline intrapulmonary bronchus (IPB) induced by VIP or nonadrenergic noncholinergic (NANC) inhibitory nervous stimulation were unaffected by the VIP receptor antagonist [Ac-Tyr1,D-Phe2]-GRF (1-29) (30 microM). A second VIP antagonist, [pCl-D-Phe6,Leu17]-VIP (30 microM), also had no effect on NANC relaxation responses or IPB sensitivity to VIP. However, responses to three of the four highest VIP concentrations were inhibited by this antagonist. These results indicate that [Ac-Tyr1,D-Phe2]-GRF (1-29) and [pCl-D-Phe6,Leu17]-VIP are not effective competitive antagonists of VIP receptors in feline airways and, hence, have but limited applicability in determining the role of VIP in mediating airway NANC inhibitory responses in this tissue.

摘要

血管活性肠肽（VIP）或非肾上腺素能非胆碱能（NANC）抑制性神经刺激所诱导的猫肺内支气管（IPB）舒张，不受VIP受体拮抗剂[Ac-Tyr1,D-Phe2]-GRF（1-29）（30微摩尔）的影响。第二种VIP拮抗剂[pCl-D-Phe6,Leu17]-VIP（30微摩尔）对NANC舒张反应或IPB对VIP的敏感性也没有影响。然而，该拮抗剂抑制了对四个最高VIP浓度中三个浓度的反应。这些结果表明，[Ac-Tyr1,D-Phe2]-GRF（1-29）和[pCl-D-Phe6,Leu17]-VIP不是猫气道中VIP受体的有效竞争性拮抗剂，因此，在确定VIP在介导该组织气道NANC抑制反应中的作用方面适用性有限。